Evidence map›Paper›PMID 29570926›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Formation of Aminocyclopentadienes from Silyldihydropyridines: Ring Contractions Driven by Anion Stabilization.

Morgan M Walker, Shuming Chen, Brandon Q Mercado, K N Houk, Jonathan A Ellman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Morgan M WalkerDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
Shuming ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095-1569, USA.
Brandon Q MercadoDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095-1569, USA.ORCID 0000-0002-8387-5261
Jonathan A EllmanDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.ORCID 0000-0001-9320-5512
Yale University · USUniversity of California, Los Angeles · US

Funding

Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiryR35GM122473 · NIGMS · YALE UNIVERSITY · PI JONATHAN A ELLMAN · 2017 to 2026
$7.6M
NIGMS NIH HHS R35 GM122473
6 · The paper itself

Abstract

Highly functionalized aminocyclopentadienes can be formed through the rearrangement of anions generated from readily prepared 6-silyl-1,2-dihydropyridines by desilylation with fluoride. The scope and generality of the reaction was defined, and diverse transformations were performed on the highly functionalized products. A mechanism and driving force for the rearrangement were identified from experiments and DFT calculations.

Indexed as

AnionsCyclopentanesDensity Functional TheoryDihydropyridinesAnionsCyclopentanesDihydropyridinesaminesdensity functional calculationsreaction mechanismsrearrangementring contraction

Identifiers

PMID29570926
PMCPMC6040663
OpenAlexW2792473073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.