ArticlePloS one2018
Intra-operative biopsy in chronic sinusitis detects pathogenic Escherichia coli that carry fimG/H, fyuA and agn43 genes coding biofilm formation.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- From presumed infection to systemic vasculitis: de novo granulomatosis with polyangiitis in pregnancy - a case report.Case reports in women's health · 2026Article
- Cyclomodulins and supplementary virulence genes as determinants of clinical severity and antimicrobial resistance in uropathogenic Escherichia coli and Klebsiella pneumoniae.World journal of microbiology & biotechnology · 2026Article
- Genomic insights into antimicrobial resistance and virulence ofFrontiers in microbiology · 2025Article
- Chronic Rhinosinusitis-Microbiological Etiology, Potential Genetic Markers, and Diagnosis.International journal of molecular sciences · 2024Review
- Analysis of nasopharyngeal microbiome patterns in Zambian infants with fatal acute febrile illness.bioRxiv : the preprint server for biology · 2023Article
- Alteration of indicator gut microbiota in patients with chronic sinusitis.Immunity, inflammation and disease · 2023Article
- May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?International journal of molecular sciences · 2022Article
- Biofilms possibly harbor occult SARS-CoV-2 may explain lung cavity, re-positive and long-term positive results.Frontiers in cellular and infection microbiology · 2022Article
- Article
- The efficacy of diluted topical povidone-iodine rinses in the management of recalcitrant chronic rhinosinusitis: a prospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Genome rearrangements induce biofilm formation in Escherichia coli C - an old model organism with a new application in biofilm research.BMC genomics · 2019Article
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Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether or not surgical biopsy of sinus tissue in chronic sinusitis, not responsive to treatment, would detect E. coli. We intended to evaluate E. coli virulence genes, therefore dispute the causal role of such an unusual microorganism in chronic sinusitis, as well as consider effective pathogen-targeted therapy. Patients with E. coli isolated by intra-operative puncture biopsy were included in the study. Genetic analysis of E. coli isolates, including phylogenetic grouping and virulence factor characteristics, were done by multiplex PCR. We identified 26 patients with chronic sinusitis, in which 26 E. coli isolates were cultured. The E. coli isolates belonged mainly to pathogenic phylogenetic group B2, and carried multiple virulence genes. Three genes in particular were present in all (100%) of examined isolates, they were (1) marker agn43 gene for forming biofilm, (2) type 1 fimbriae (fimG/H gene) and (3) yersiniabactin receptor (fyuA). Furthermore, a pseudo-phylogenetic tree of virulence genes distribution revealed possible cooperation between agn43, fimG/H, and fyuA in the coding of biofilm formation. Intra-operative-biopsy and culture-based therapy, targeting the isolated E. coli, coincided with long-term resolution of symptoms. This is the first report demonstrating an association between a highly pathogenic E. coli, chronic sinus infection, and resolution of symptoms upon E. coli targeted therapy, a significant finding due to the fact that E. coli has not been considered to be a commensal organism of the oropharynx or sinuses. We postulate that the simultaneous presence of three genes, each coding biofilm formation, may in part account for the chronicity of E. coli sinusitis.
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