Evidence map›Paper›PMID 29570631›Full record

ArticleToxins2018

Phenotypic Variation in Mojave Rattlesnake (Crotalus scutulatus) Venom Is Driven by Four Toxin Families.

Jason L Strickland, Andrew J Mason, Darin R Rokyta, Christopher L Parkinson

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Venom phenotype conservation suggests integrated specialization in a lizard-eating snake.Toxicon : official journal of the International Society on Toxinology · 2023
    Article
  11. Article
  12. Article
  13. Snake Bite Management: A Scoping Review of the Literature.Plastic and reconstructive surgery. Global open · 2021
    Article
  14. Article
  15. Review
  16. The origin and diversification of a novel protein family in venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jason L StricklandDepartment of Biology, University of Central Florida, 4110 Libra Drive, Orlando, FL 32816, USA. Jason.Strickland@ucf.edu.ORCID 0000-0002-1927-7259
Andrew J MasonDepartment of Biological Sciences, Clemson University, 190 Collings St., Clemson, SC 29634, USA. ajmason@clemson.edu.ORCID 0000-0003-0297-1313
Darin R RokytaDepartment of Biological Science, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306, USA. drokyta@bio.fsu.edu.ORCID 0000-0002-0356-2178
Christopher L ParkinsonDepartment of Biology, University of Central Florida, 4110 Libra Drive, Orlando, FL 32816, USA. viper@clemson.edu.ORCID 0000-0002-2020-6992
University of Central Florida · USClemson University · USFlorida State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenotypic diversity generated through altered gene expression is a primary mechanism facilitating evolutionary response in natural systems. By linking the phenotype to genotype through transcriptomics, it is possible to determine what changes are occurring at the molecular level. High phenotypic diversity has been documented in rattlesnake venom, which is under strong selection due to its role in prey acquisition and defense. Rattlesnake venom can be characterized by the presence (Type A) or absence (Type B) of a type of neurotoxic phospholipase A 2 (PLA 2 ), such as Mojave toxin, that increases venom toxicity. Mojave rattlesnakes (

Indexed as

CrotalusAnimalsCrotalid VenomsExocrine GlandsLectins, C-TypeMetalloproteasesPhenotypePhospholipases A2Reptilian ProteinsTranscriptomeCrotalid VenomsLectins, C-TypeMetalloproteasesPhospholipases A2Reptilian ProteinsC-type lectinshemorrhagicMojave toxinmyotoxin aneurotoxicphospholipase A2RNA-seqsnake venom metalloproteinases

Identifiers

PMID29570631
PMCPMC5923301
OpenAlexW2793547367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.