Trial reportMedicine and science in sports and exercise2018
Overview of the NASA 70-day Bed Rest Study.
Trial report in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Efficacy of Testosterone plus NASA Exercise Countermeasures during Head-Down Bed Rest.Medicine and science in sports and exercise · 2018Trial
- Exercise Training Mitigates Multisystem Deconditioning during Bed Rest.Medicine and science in sports and exercise · 2018Trial
- Exercise effects on bed rest-induced brain changes.PloS one · 2018Trial
- Personalization and Fortification of In-Space Manufactured Emulsified Beverages for Long-Term Space Travel.Comprehensive reviews in food science and food safety · 2026Review
- Medial gastrocnemius activation during graded axial hypergravity induced by short-arm human centrifugation.European journal of applied physiology · 2026Article
- Spaceward senses: examining retronasal aroma and mouthfeel perception in simulated space-microgravity environments.NPJ science of food · 2025Article
- Initiating Sensory Science Research in Space Conditions-Current Practices and Future Perspectives.Comprehensive reviews in food science and food safety · 2025Review
- Exploring the Impact of Microgravity on Gene Expression: Dysregulated Pathways and Candidate Repurposed Drugs.International journal of molecular sciences · 2025Article
- Myonuclear and satellite cell content of the vastus lateralis and soleus with 70 days of simulated microgravity and the NASA SPRINT exercise program.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Exploring consumer acceptability of leafy greens in earth and space immersive environments using biometrics.NPJ science of food · 2024Article
- Using noninvasive imaging to assess manual lymphatic drainage on lymphatic/venous responses in a spaceflight analog.NPJ microgravity · 2024Article
- Review
- NASA SPRINT exercise program efficacy for vastus lateralis and soleus skeletal muscle health during 70 days of simulated microgravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Exercise microdosing for skeletal muscle health applications to spaceflight.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.NPJ microgravity · 2024Article
- Personality matters in extremely demanding environments: A bed rest performance study.Frontiers in psychology · 2024Article
- Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CONPJ microgravity · 2022Article
- Mechanical deconditioning of the heart due to long-term bed rest as observed on seismocardiogram morphology.NPJ microgravity · 2022Article
- Virtual Reality "exergames": A promising countermeasure to improve motivation and restorative effects during long duration spaceflight missions.Frontiers in physiology · 2022Article
- The Cardiovascular System in Space: Focus on In Vivo and In Vitro Studies.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe purpose of this article was to provide an overview of the National Aeronautics and Space Administration (NASA) 70-day Bed Rest Study. The integrated complement of investigations and the standardized bed rest environment that served as the platform for this study complement are described. Outcomes of the studies will not be presented here but will be reported in separate publications.
methodsA set of studies running in an integrated fashion along the entire period (pre-, in-, and post-bed rest) and using the same subjects is referred in this article as "the campaign" or "complement." NASA selected eight individual studies to participate in the 70-d bed rest campaign. These studies were integrated to increase efficiency in the utilization of resources and to share common measures among the investigations. In addition to the individual studies addressing specific aims, a battery of standardized measures was included. Standard measures target a wide range of physiologic systems and represent some of the testing routinely done on astronauts. Bed rest subjects underwent rigorous medical and psychological screening. Standardized conditions included 70 d of bed rest in a 6° head-down tilt position. Subjects' vital signs, body weight, and fluid intake and output were measured daily. A standardized diet was provided to ensure consistent nutritional intake across subjects. Exercising subjects were prescribed individualized aerobic and resistance training 6 d·wk performed in a horizontal body position. Subjects in the testosterone supplementation countermeasure group received testosterone enanthate injections at 2-wk intervals during bed rest.
conclusionLong-duration head-down tilt bed rest provided a suitable platform for examining physiologic effects of spaceflight and testing countermeasures in a ground-based model. Integrating studies into a complement is an effective way to support multiple investigations while minimizing the number of subjects to answer many research questions.
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