ArticleJournal of hypertension2018
Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults.
Article in Journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Exploring the Plasma Fatty Acid Signature of Primary Aldosteronism: Comparison with Essential Hypertension and Longitudinal Therapy Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Circulating fatty acids, genetic susceptibility and hypertension: a prospective cohort study.Frontiers in nutrition · 2024Article
- Association between blood N-3 fatty acid levels and the risk of coronavirus disease 2019 in the UK Biobank.The American journal of clinical nutrition · 2023Article
- Prevalence of hypertension in endemic and non-endemic areas of Keshan disease: A cross-sectional study in rural areas of China.Frontiers in nutrition · 2023Article
- Dietary Approaches to Stop Hypertension via Indo-Mediterranean Foods, May Be Superior to DASH Diet Intervention.Nutrients · 2022Review
- Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-DHF randomized controlled trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Omega-3 Polyunsaturated Fatty Acids-Vascular and Cardiac Effects on the Cellular and Molecular Level (Narrative Review).International journal of molecular sciences · 2022Review
- Review
- The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation.Nutrients · 2021Article
- Article
- Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study).Frontiers in cardiovascular medicine · 2021Article
- The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance.Frontiers in cardiovascular medicine · 2021Review
- Association of circulating saturated fatty acids with the risk of pregnancy-induced hypertension: a nested case-control study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- [Confusion about the effects of omega-3 fatty acids : Contemplation of study data taking the omega-3 index into consideration].Der Internist · 2019Review
- Associations of medium and long chain omega-3 polyunsaturated fatty acids with blood pressure in Hispanic and non-Hispanic smokers and nonsmokers.Prostaglandins, leukotrienes, and essential fatty acids · 2019Article
- Avoiding holiday seasonal weight gain with nutrient-supported intermittent energy restriction: a pilot study.Journal of nutritional science · 2019Article
- Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats.Journal of diabetes research · 2018Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOmega-3 fatty acids (n - 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n - 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals' omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults.
methodsThe current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25-41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders.
resultsMedian Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was -2.67 mmHg (-4.83; -0.51; P = 0.02) and -2.30 mmHg (-3.92; -0.68; P = 0.005) for 24-h SBP and DBP, respectively.
conclusionA higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n - 3 FA may be a strategy for primary prevention of hypertension.
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