Evidence map›Paper›PMID 29570237›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2018

Cytomegalovirus resistance in CD34

Seong Jin Kim, Yao-Ting Huang, Julia Foldi, Yeon Joo Lee, Molly Maloy, Sergio A Giralt, Ann A Jakubowski, Genovefa A Papanicolaou

Abstract read
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seong Jin KimInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yao-Ting HuangInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Julia FoldiInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yeon Joo LeeInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2997-0217
Molly MaloyAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sergio A GiraltWeill Medical College, Cornell University, New York, NY, USA.
Ann A JakubowskiWeill Medical College, Cornell University, New York, NY, USA.
Genovefa A PapanicolaouInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
T LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHEINBERG, DAVID A · 1985 to 2023
$59.0M
NCI NIH HHS P01 CA023766NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) viremia after CD34

methodsWe retrospectively reviewed 220 consecutive, CMV-seropositive recipients (R+), who received CD34

resultsOne hundred and sixty-one (73%) patients developed CMV viremia and 47 (29% of viremic and 21% of total patients) had CMV resistance testing by one-year from HCT. CMV resistance was confirmed in 19 (12% of viremic and 9% of total) patients and was identified >3 months from HCT in 90% of patients. Twelve patients had mutations in UL97 only; the remaining 7 patients had mutations in UL54 only or UL54 and UL97. By 1 year from HCT, 11 of 19 (58%) patients with mutations had CMV end-organ disease. CMV-related mortality in patients with resistance was 42%.

conclusionsNine percent of CMV R+, CD34

Indexed as

AdultAgedAntigens, CD34Cohort StudiesCytomegalovirusCytomegalovirus InfectionsDNA-Directed DNA PolymeraseFemaleGenotypeHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedMutationRetrospective StudiesTransplant RecipientsAntigens, CD34DNA-Directed DNA PolymeraseUL54 protein, Human herpesvirus 5Viral ProteinsCD34+-selectedCytomegalovirusGenotypeHematopoietic stem cell transplantationResistance

Identifiers

PMID29570237
PMCPMC5988949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.