ArticleEuropean journal of histochemistry : EJH2018
What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study.
Article in European journal of histochemistry : EJH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Treatment of multiple adjacent gingival recessions with an acellular dermal matrix or a connective tissue graft: a Meta-analysis.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Pooled it
- Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial.BMC oral health · 2025Trial
- The role of tensor fascia lata (TFL) graft in wound treatment: a case report.International journal of surgery case reports · 2026Article
- Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy.Journal of periodontology · 2026Review
- Complications associated with acellular dermal matrix use in implant-based breast reconstruction.Gland surgery · 2026Review
- Capsule histology in breast reconstruction: different materials lead to different tissue responses - a case series.Frontiers in surgery · 2026Article
- Article
- Immunogenicity and Integration of a Decellularized Extracellular Matrix-Based Scaffold for the Reconstruction of Human Foreskin: A Preclinical Animal Study.Bioengineering (Basel, Switzerland) · 2025Article
- Effective application of an innovative acemannan-enriched glycolipid sphere dressing in diabetic foot ulcer wound healing: A case report and review of literature.World journal of clinical cases · 2025Article
- Biologic Response With and Without Acellular Dermal Matrix in Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Use of TIGR Synthetic Reabsorable Mesh in Primary Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- The safety and anti-adhesive effect of acellular dermal matrix application after thyroid surgery: a multicenter randomized controlled trial.Annals of surgical treatment and research · 2025Article
- Acellular dermal matrices in reconstructive surgery; history, current implications and future perspectives for surgeons.World journal of clinical cases · 2024Review
- A Histological and Biomechanical Analysis of Human Acellular Dermis (HAD) Created Using a Novel Processing and Preservation Technique.Indian journal of orthopaedics · 2024Article
- Pre-pectoral Breast Reconstruction: Surgical and Patient-Reported Outcomes of Two-Stages vs Single-Stage Implant-Based Breast Reconstruction.Aesthetic plastic surgery · 2024Article
- Article
- Implant-Based Breast Reconstruction with Bovine Pericardium: Our Approach Using TutopatchAesthetic plastic surgery · 2024Review
- Histopathologic Analysis of a Recalcitrant Calcaneal Wound Treated Using a Synthetic Hybrid-scale Fiber Matrix.Plastic and reconstructive surgery. Global open · 2024Article
- Acellular dermal matrix in urethral reconstruction.Frontiers in pediatrics · 2024Review
- How Porcine Acellular Dermal Matrix Influences the Development of the Breast Capsule 1 Year after Implantation: A Histopathological Analysis.Plastic and reconstructive surgery. Global open · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acellular matrices are used for various purposes and they have been studied extensively for their potential roles in regenerating tissues or organs. The acellular matrix generates physiological cues that mimic the native tissue microenvironment. Acellular dermal matrix (ADM) is a soft connective tissue graft generated by a decellularization process that preserves the intact extracellular skin matrix. Upon implantation, this structure serves as a scaffold for donor-side cells to facilitate subsequent incorporation and revascularization. In breast reconstruction, ADM is used mainly for lower pole coverage and the shaping of a new breast. It helps control the positioning of the implant in the inframammary fold, and prevent the formation of contractile pseudocapsule around the breast implant. In this study, we provide a comprehensive histological description of ADM used for human breast reconstruction over the course of several months following implementation. Using immunohistochemical methods (a panel of 12 antibodies) coupled with optical and transmission electron microscopy, we confirmed that the original acellular dermal matrix became recolonized by fibroblasts and myofibroblasts, and also by various other free cells of the connective tissue (lymphocytes, macrophages and multinucleated giant cells, granulocytes, mast cells) after implantation into the patient's body. Within the implanted ADM, there was a relatively rapid ingrowth of blood vessels. Lymphatic vessels were only detected in one case 9 months after the implantation of the ADM. These results suggest that lymphangiogenesis is a longer process than angiogenesis.
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Registered trials
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