ArticleMagnetic resonance in medicine2018
Chemical exchange-sensitive spin-lock (CESL) MRI of glucose and analogs in brain tumors.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026Review
- FlexCENT: A frequency-flexible CEST imaging network combining frequency offset encoding and three-dimensional U-Net.Magnetic resonance letters · 2026Article
- Generalization of Optimal Control Saturation Pulse Design for Robust and High CEST Contrast.Magnetic resonance in medicine · 2026Article
- Radiofrequency bandwidth effects in direct saturation dynamic glucose enhanced MRI at 3T.Frontiers in neuroscience · 2026Article
- Measuring cerebral glucose metabolism by chemical exchange-sensitive spin-lock (CESL) MRI of 2-deoxy-D-glucose in rodents.PloS one · 2026Article
- Dynamic glucose enhanced imaging using direct water saturation.Magnetic resonance in medicine · 2025Article
- Dynamic glucose-enhanced MRI of gliomas: A preliminary clinical application.NMR in biomedicine · 2025Article
- Amide proton transfer MRI at 9.4 T for differentiating tissue acidosis in a rodent model of ischemic stroke.Magnetic resonance in medicine · 2024Article
- Glymphatic influx and clearance are perturbed in Huntington's disease.JCI insight · 2024Article
- Effect of inhaled oxygen level on dynamic glucose-enhanced MRI in mouse brain.Magnetic resonance in medicine · 2024Article
- Adjustment of rotation and saturation effects (AROSE) for CEST imaging.Magnetic resonance in medicine · 2024Article
- Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system.Frontiers in psychiatry · 2024Review
- An update on liver chemical exchange saturation transfer imaging with a focus on clinical translation.Quantitative imaging in medicine and surgery · 2023Article
- Tissue response curve-shape analysis of dynamic glucose-enhanced and dynamic contrast-enhanced magnetic resonance imaging in patients with brain tumor.NMR in biomedicine · 2023Article
- In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023Review
- Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.Magnetic resonance in medicine · 2023Article
- Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Average saturation efficiency filter (ASEF) for CEST imaging.Magnetic resonance in medicine · 2022Article
- Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges.Pharmaceutics · 2022Review
- What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report.Magma (New York, N.Y.) · 2022Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeGlucose uptake and metabolism can be measured by chemical exchange-sensitive spin-lock (CESL) MRI with an administration of glucose or its analogs. This study investigates the sensitivity, the spatiotemporal characteristics, and the signal source of glucoCESL with a 9L rat brain tumor model.
methodsDynamic CESL MRI with intravenous injection of D-glucose, 2-deoxy-D-glucose (2DG), and L-glucose were measured and compared with gadolinium-based dynamic contrast-enhanced (DCE) MRI.
resultsThe CESL signals with an injection of glucose or analogs have faster and larger changes in tumors than normal brain tissue. In tumors, the CESL signal with 2DG injection has larger and slower peak response than that with D-glucose due to the accumulation of 2DG and 2DG-6-phosphate in the intracellular compartment, whereas L-glucose, which cannot be transported intracellularly by glucose transporters, only induces a small change. The initial glucoCESL maps (< 4 minutes) are qualitatively similar to DCE maps, whereas later maps (> 4 minutes) show more widespread responses. The rise times of D-glucose-CESL and 2DG-CESL signals in the tumor are slower than that of DCE. Our data suggest that the initial CESL contrast primarily reflects a passive increase of glucose content in the extracellular space of tumors due to a higher vascular permeability, whereas the later period may have a significant contribution from the uptake/metabolism of glucose in the intracellular compartment.
conclusionsOur results demonstrate that glucoCESL MRI has both extracellular and intracellular contributions, and can be a useful tool for measurements of both vascular permeability and glucose uptake in tumors.
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