ArticleInternational journal of cancer2018
Adiposity and breast cancer risk in postmenopausal women: Results from the UK Biobank prospective cohort.
Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Life course socioeconomic position and body composition in adulthood: a systematic review and narrative synthesis.International journal of obesity (2005) · 2021Pooled it
- Abdominal visceral and subcutaneous adipose tissue associations with postmenopausal breast cancer incidence.JNCI cancer spectrum · 2025Trial
- Adiposity and risk of breast cancer in 280 000 Chinese women: a prospective cohort study.International journal of epidemiology · 2026Observational
- Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Comparing waist circumference with body mass index on obesity-related cancer risk: a pooled Swedish study.Journal of the National Cancer Institute · 2025Article
- Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines.Genes & diseases · 2025Review
- Adiposity and risks of gastrointestinal cancers: A 10-year prospective study of 0.5 million Chinese adults.International journal of cancer · 2025Article
- Cellular senescence predicts breast cancer risk from benign breast disease biopsy images.Breast cancer research : BCR · 2025Article
- Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles.Scientific reports · 2025Article
- The association between the healthy lifestyle index and MRI-derived body composition measurements in the UK Biobank study.Scientific reports · 2025Article
- Assessing the impact of gout on cancer risk and the role of healthy lifestyles.Frontiers in oncology · 2025Article
- New role of fat-free mass in cancer risk linked with genetic predisposition.Scientific reports · 2024Article
- FGFR1 Signaling Facilitates Obesity-Driven Pulmonary Outgrowth in Metastatic Breast Cancer.Molecular cancer research : MCR · 2024Article
- Association ofmedRxiv : the preprint server for health sciences · 2023Article
- Surrogate Adiposity Markers and Mortality.JAMA network open · 2023Article
- Article
- Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.Breast cancer research : BCR · 2023Article
- Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation.British journal of cancer · 2023Article
- Association of Body Fat Distribution and Risk of Breast Cancer in Pre- and Postmenopausal Women.Obesity facts · 2023Article
- Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study.Breast cancer research : BCR · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Body size is an important modifiable risk factor for postmenopausal breast cancer. However, it remains unclear whether direct measures of fat mass are better indicators of risk than anthropometric measures, or whether central adiposity may contribute to risk beyond overall adiposity. We analyzed data from 162,691 postmenopausal women in UK Biobank followed from 2006 to 2014. Body size was measured by trained technicians. Multivariable-adjusted Cox regression was used to estimate relative risks. Analyses were stratified by age at recruitment, region and socioeconomic status, and adjusted for family history of breast cancer, age at menarche, age at first birth, parity, age at menopause, previous hormone replacement therapy use, smoking, alcohol intake, height, physical activity and ethnicity. We observed 2,913 incident invasive breast cancers during a mean 5.7 years of follow-up. There was a continuous increase in risk of postmenopausal breast cancer with increasing adiposity, across all measures. The point estimate, comparing women in the top (median 37.6 kg) to bottom (median 17.6 kg) quartile of body fat mass was 1.70 (95% confidence interval 1.52-1.90). The magnitudes of the associations between per SD increase in BMI and body fat mass with breast cancer risk were similar, suggesting impedance measures of fat were not substantially better indicators of risk than anthropometric measures. After adjusting for body fat mass, the associations between anthropometric measures of central adiposity and breast cancer risk were attenuated. The magnitude of risk, across all measures of adiposity, was greater in women who had been postmenopausal for 12 or more years.
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