Evidence map›Paper›PMID 29569651›Full record

ArticleTheranostics2018

Resistant to Targeted Therapy - Aim for Metabolic Liabilities.

André Lima Queiroz, Helin Vakifahmetoglu-Norberg, Erik Norberg

Open access · goldAbstract readEditorialComment
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.International journal of biological sciences · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

André Lima QueirozDepartment of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, SE-171 77, Stockholm, Sweden.
Helin Vakifahmetoglu-NorbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, SE-171 77, Stockholm, Sweden.
Erik NorbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, SE-171 77, Stockholm, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of targeted therapies generated much optimism when discovered. Targeted therapies, are however associated with rapid acquisition of resistance. In a recent study by Dong

Indexed as

Erlotinib HydrochloridePhosphoglycerate DehydrogenaseAdenocarcinoma of LungCell Line, TumorDrug Resistance, NeoplasmErbB ReceptorsHumansLung NeoplasmsMutationEGFR protein, humanErbB ReceptorsErlotinib HydrochloridePhosphoglycerate DehydrogenaseEGFRLung AdenocarcinomasLung CancerNon-small Cell Lung CarcinomasPHGDHSerineTumor Metabolism

Identifiers

PMID29569651
PMCPMC5858517
OpenAlexW2789700862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.