Evidence map›Paper›PMID 29569622›Full record

ReviewNature reviews. Endocrinology2018

Global epidemiology of hyperthyroidism and hypothyroidism.

Peter N Taylor, Diana Albrecht, Anna Scholz, Gala Gutierrez-Buey, John H Lazarus, Colin M Dayan, Onyebuchi E Okosieme

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 684 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
684citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04976816 phase2 / phase3completednot on this mapstarted 2021, after this paper: background citation

Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid-Related Upper Lid Retraction With and Without Proptosis

TypeinterventionalSponsorAssiut UniversityRan2021 to 2023Enrolled92ConditionsThyroid Eye DiseaseArmsperi-levator betamethasone injection, peri-levator triamcinolone injection, peri-levator and retrobulbar betamethasone injection, peri-levator and retrobulbar triamcinolone injection
NCT05143918 unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Quality of Life Among Hypothyroid Patients in Assiut University Hospitals

TypeobservationalSponsorAssiut UniversityRan2021 to 2023Enrolled176ConditionsHypothyroidismArmsassessment of quality of life using questionnaire
3 · Its place in the literature

Who cites it

684 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  10. Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026
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624 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Peter N TaylorThyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
Diana AlbrechtUniversity Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany.
Anna ScholzThyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
Gala Gutierrez-BueyClinica Universidad de Navarra, Department of Endocrinology and Nutrition, Pamplona, Spain.
John H LazarusThyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
Colin M DayanThyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
Onyebuchi E OkosiemeThyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common conditions with potentially devastating health consequences that affect all populations worldwide. Iodine nutrition is a key determinant of thyroid disease risk; however, other factors, such as ageing, smoking status, genetic susceptibility, ethnicity, endocrine disruptors and the advent of novel therapeutics, including immune checkpoint inhibitors, also influence thyroid disease epidemiology. In the developed world, the prevalence of undiagnosed thyroid disease is likely falling owing to widespread thyroid function testing and relatively low thresholds for treatment initiation. However, continued vigilance against iodine deficiency remains essential in developed countries, particularly in Europe. In this report, we review the global incidence and prevalence of hyperthyroidism and hypothyroidism, highlighting geographical differences and the effect of environmental factors, such as iodine supplementation, on these data. We also highlight the pressing need for detailed epidemiological surveys of thyroid dysfunction and iodine status in developing countries.

Indexed as

AnimalsFemaleHumansHyperthyroidismHypothyroidismIodineMaleThyroid DiseasesIodine

Identifiers

PMID29569622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.