Evidence map›Paper›PMID 29569621›Full record

ReviewNature reviews. Endocrinology2018

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.

Héctor F Escobar-Morreale

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03151005. Cited by 912 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
912citing papers in PubMed, 11 pooled it
112.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03151005 phase4completed

Randomized Clinical Trial to Evaluate The Effect of Metformin-GLP-1 Receptor Agonist Versus Oral Contraceptive (OC) Therapy on Reproductive Disorders and Cardiovascular Risks in Overweight Polycystic Ovarian Syndrome (PCOS) Patients

Ran2017Enrolled70Registered outcomes5Posted comparisons0ConditionsObesity, Overweight, Polycystic Ovary Syndrome (PCOS)ArmsMetformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
PMID 28646699PMID 28860713PMID 24389146PMID 28463030PMID 26426951PMID 22777527PMID 20471009PMID 14688154PMID 30459598PMID 12046553other papers from this trial
Open the trial in the graph
NCT03841981 recruitingnot on this mapstarted 2020, after this paper: background citation

Amount, Distribution and Dysfunction of Body Fat as Determinants of Female Gonadal Dysfunction: From Functional Hypothalamic Amenorrhea to the Polycystic Ovary Syndrome

TypeobservationalSponsorFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalRan2020 to 2025Enrolled50ConditionsPolycystic Ovary Syndrome, Hypothalamic AmenorrheaArmsAnthropometric and physical examination, Indirect calorimetry, accelerometer and seven-day dietary recall, Biochemical, hormonal and metabolic phenotyping, Sonographic studies, 24-hour Ambulatory blood pressure monitoring
NCT07490964 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pathogenesis of Functional Hyperandrogenism in Women With Type 1 Diabetes Mellitus: From Genetic-molecular Mechanisms to Clinical Phenotype.

TypeobservationalSponsorFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalRan2026 to 2028Enrolled60ConditionsType 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)ArmsType 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
3 · Its place in the literature

Who cites it

912 citing papers in PubMed, 11 syntheses or guidelines pooled it, 2,011 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Review
  18. Article
  19. Review
  20. Article

852 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Héctor F Escobar-MorrealeDepartment of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Universidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in premenopausal women. Heterogeneous by nature, PCOS is defined by a combination of signs and symptoms of androgen excess and ovarian dysfunction in the absence of other specific diagnoses. The aetiology of this syndrome remains largely unknown, but mounting evidence suggests that PCOS might be a complex multigenic disorder with strong epigenetic and environmental influences, including diet and lifestyle factors. PCOS is frequently associated with abdominal adiposity, insulin resistance, obesity, metabolic disorders and cardiovascular risk factors. The diagnosis and treatment of PCOS are not complicated, requiring only the judicious application of a few well-standardized diagnostic methods and appropriate therapeutic approaches addressing hyperandrogenism, the consequences of ovarian dysfunction and the associated metabolic disorders. This article aims to provide a balanced review of the latest advances and current limitations in our knowledge about PCOS while also providing a few clear and simple principles, based on current evidence-based clinical guidelines, for the proper diagnosis and long-term clinical management of women with PCOS.

Indexed as

AnimalsFemaleHumansHyperandrogenismInsulin ResistanceMetabolic DiseasesObesityPolycystic Ovary Syndrome

Identifiers

PMID29569621
OpenAlexW2793887346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.