Evidence map›Paper›PMID 29569488›Full record

ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2018

Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.

Frank C Ko, Jia Li, Daniel J Brooks, Seward B Rutkove, Mary L Bouxsein

Abstract read
In one paragraph

Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Frank C Koa Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center , Boston , MA , USA.
Jia Lic Department of Neurology , Harvard Medical School , Boston , MA , USA.
Daniel J Brooksa Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center , Boston , MA , USA.
Seward B Rutkovec Department of Neurology , Harvard Medical School , Boston , MA , USA.
Mary L Bouxseina Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center , Boston , MA , USA.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

Electrical Impedance Myography in an Animal ModelR01NS055099 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2007 to 2022
$5.1M
Innovative Ultrasound Technology in Neuromuscular DiseaseK24NS060951 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2008 to 2017
$1.5M
NINDS NIH HHS K24 NS060951NINDS NIH HHS R01 NS055099
6 · The paper itself

Abstract

In addition to muscle weakness, amyotrophic lateral sclerosis (ALS) is associated with an increased incidence of skeletal fractures. The SOD1

Indexed as

Amyotrophic Lateral SclerosisAnimalsBiomechanical PhenomenaBone and BonesDisease Models, AnimalDisease ProgressionFemaleFractures, BoneMiceMice, TransgenicMuscle, SkeletalStress, MechanicalSuperoxide DismutaseTomography Scanners, X-Ray ComputedX-Ray MicrotomographySOD1 G93A proteinSuperoxide DismutaseALS mouse modelbone biomechanicsbone strengthfracture toughnessmicroCT

Identifiers

PMID29569488
PMCPMC6141014
OpenAlexW2792941949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.