Evidence map›Paper›PMID 29569388›Full record

ArticleImmunology2018

Antigen-specific airway IL-33 production depends on FcγR-mediated incorporation of the antigen by alveolar macrophages in sensitized mice.

Takeshi Nabe, Masaya Matsuda, Tomoki Ishida, Nau Tsujimoto, Hitomi Kido, Haruna Kanaya, Hiromu Takahashi, Naoki Takemoto, Miku Nomura, Keiichi Ishihara and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Takeshi NabeLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.ORCID 0000-0002-5225-8375
Masaya MatsudaLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Tomoki IshidaLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Nau TsujimotoLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Hitomi KidoDepartment of Pharmacology, Kyoto Pharmaceutical University, Kyoto, Japan.
Haruna KanayaLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Hiromu TakahashiLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Naoki TakemotoLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Miku NomuraLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Keiichi IshiharaDepartment of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
Satoshi AkibaDepartment of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
Nobuaki MizutaniFaculty of Pharmaceutical Sciences, Kinjo Gakuin University, Nagoya, Japan.
Setsunan University · JPKyoto Pharmaceutical University · JPKinjo Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although interleukin (IL)-33 is a candidate for the aggravation of asthma, the mechanisms underlying antigen-specific IL-33 production in the lung are unclear. Therefore, we analysed the mechanisms in mice. Intra-tracheal administration of ovalbumin (OVA) evoked increases in IL-33 and IL-33 mRNA in the lungs of both non-sensitized and OVA-sensitized mice, and the increases in the sensitized mice were significantly higher than in the non-sensitized mice. However, intra-tracheal administration of bovine serum albumin did not increase the IL-33 level in the OVA-sensitized mice. Depletion of neither mast cells/basophils nor CD4

Indexed as

AnimalsAntibodies, MonoclonalAntigen-Antibody ReactionsInterleukin-33Macrophages, AlveolarMiceMice, Inbred BALB CReceptors, IgGAntibodies, MonoclonalIl33 protein, mouseInterleukin-33Receptors, IgGairway inflammationB-cellsIgGinterleukin-33macrophages

Identifiers

PMID29569388
PMCPMC6099176
OpenAlexW2790627758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.