Evidence map›Paper›PMID 29569376›Full record

ArticlePediatric dermatology2018

Contrasting features of childhood and adolescent melanomas.

Diana W Bartenstein, Cassandra M Kelleher, Alison M Friedmann, Lyn M Duncan, Hensin Tsao, Arthur J Sober, Elena B Hawryluk

Abstract readComparative Study
In one paragraph

Article in Pediatric dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Imaging of pediatric cutaneous melanoma.Pediatric radiology · 2019
    Review
  7. An 18-year Study of Malignant Melanoma in Childhood and Adolescence.Plastic and reconstructive surgery. Global open · 2019
    Article
  8. Pediatric melanoma-The whole (conflicts of interest) story.International journal of women's dermatology · 2019
    Review
  9. Review
  10. The Challenges of Pediatric Drug Development.Current therapeutic research, clinical and experimental · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Diana W BartensteinSchool of Medicine, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8850-9551
Cassandra M KelleherSchool of Medicine, Harvard University, Boston, MA, USA.
Alison M FriedmannSchool of Medicine, Harvard University, Boston, MA, USA.
Lyn M DuncanSchool of Medicine, Harvard University, Boston, MA, USA.
Hensin TsaoSchool of Medicine, Harvard University, Boston, MA, USA.
Arthur J SoberSchool of Medicine, Harvard University, Boston, MA, USA.
Elena B HawrylukSchool of Medicine, Harvard University, Boston, MA, USA.
Harvard University · USTufts University · US

Funding

Molecular Risk Assessment in Hereditary MelanomaK24CA149202 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TSAO, HENSIN · 2010 to 2019
$1.9M
NCI NIH HHS K24 CA149202
6 · The paper itself

Abstract

BACKGROUND/

objectivesMelanoma in children and adolescents is uncommon, and there are limited data on pediatric outcomes. Several studies have shown comparable survival rates in children and adults, but other research demonstrates that prepubescent children have more favorable outcomes. This study aims to compare childhood and adolescent melanoma.

methodsRetrospective cohort study of children who received a melanoma diagnosis at the Massachusetts General Hospital between January 1, 1995, and December 21, 2016. Childhood melanoma is defined as disease occurring in patients younger than 11 years old, and adolescent melanoma is defined as disease occurring in patients 11 to 19 years old. Patients diagnosed with ocular melanoma and borderline tumors of uncertain malignant potential were excluded. This analysis compares clinical, histopathologic, and outcome characteristics of childhood and adolescent melanoma.

resultsThirty-two children with melanoma were identified (12 children, 20 adolescents). The spitzoid melanoma subtype was significantly more common in children (6/12) than adolescents (2/20) (P = .01). Four adolescents and no children with melanoma died from melanoma, and survival was significantly different between the age groups (P = .04). Median follow-up time for survivors was 3.6 years.

conclusionsThese results suggest that children and adolescents present with different melanoma subtypes and that adolescents have a more aggressive disease course than children.

Indexed as

AdolescentAge FactorsChildChild, PreschoolCohort StudiesFemaleHumansMaleMelanomaRetrospective StudiesSkin NeoplasmsSurvival RateYoung Adultbumpslumpsmalignantneoplasms

Identifiers

PMID29569376
PMCPMC6476315
OpenAlexW2792914890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.