Evidence map›Paper›PMID 29569221›Full record

ArticleJournal of natural medicines2018

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl

Tomohiro Numata, Kaori Sato-Numata, Yasunobu Okada, Ryuji Inoue

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural medicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tomohiro NumataDepartment of Physiology, Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka, 814-0180, Japan. numata@fukuoka-u.ac.jp.ORCID http://orcid.org/0000-0002-5719-4884
Kaori Sato-NumataJapan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan.
Yasunobu OkadaDepartment of Molecular Cell Physiology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.
Ryuji InoueDepartment of Physiology, Graduate School of Medical Sciences, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka, 814-0180, Japan. inouery@fukuoka-u.ac.jp.
Fukuoka University · JPJapan Society for the Promotion of Science · JPKyoto Prefectural University of Medicine · JP

Funding

Japan Society for the Promotion of Science No. 15K08197
6 · The paper itself

Abstract

Constipation is a common symptom frequently compromising the quality of daily life. Several mechanistically different drugs have been used to mitigate constipation, including Japanese herbal (Kampo) medicines. However, the mechanisms of their actions are often not well understood. Here we aimed to investigate the molecular mechanisms underlying the effects of Junchoto (JCT), a Kampo medicine empirically prescribed for chronic constipation. Cl

Indexed as

AnimalsCaco-2 CellsChloridesConstipationCystic Fibrosis Transmembrane Conductance RegulatorHEK293 CellsHumansIntestinal MucosaIntestinesMedicine, KampoTransfectionCFTR protein, humanChloridesCystic Fibrosis Transmembrane Conductance RegulatorCFTRHerbal medicineIntestinal fluidJunchotoKampo

Identifiers

PMID29569221
PMCPMC5960480
OpenAlexW2793044325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.