ArticleInternational urology and nephrology2018
Effect of pregnancy on cooling tone and rhythmic contractions of the rat urinary bladder.
Article in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Developmental exposure to a human-relevant PCB mixture: impacts on PCB congeners, metabolites, and drug-metabolizing enzymes in the bladder of post-weaning mice.Archives of toxicology · 2026Article
- Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase.International urology and nephrology · 2019Article
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1 author at 1 institution in 1 country.
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Abstract
objectivesPregnancy is a physiological alteration that can affect urinary bladder. Cooling of urinary bladder smooth muscle is known as a potent stimulus to micturition due to an increase in muscle tone. The current study investigates the effects of pregnancy on cooling tone and on the rhythmic contractions of the urinary bladder.
methodsTwenty-four rats were used in this study as control group (non-pregnant) and pregnant group (18-20-day pregnancy). Isolated rat urinary muscle strips were suspended in organ baths containing Krebs' solution for isometric tension recording.
resultsCooling from 37 to 5 °C induced a rapid and reproducible increase in basal tone, proportional to cooling temperature. Cooling also increased the rhythmic activity (amplitude and frequency) at 30 and 25 °C, then decreased at 20 °C, and abolished at 15-5 °C. These responses were more pronounced in pregnant group than in control group. Rhythmic contractions were abolished in calcium-free, EGTA (1 mM)-containing Krebs' solution and in the presence of nifedipine, while they were not affected by CPA or TTX in both groups. Our investigation showed that the influx of extracellular calcium is important in inducing the rhythmic contractions.
conclusionsPregnancy increases cooling-induced contraction in pregnant rat urinary preparations and its rhythmic contractions including amplitude and frequency than non-pregnant rat. Rhythmic contractions are myogenic in nature and highly extracellular calcium dependent. They may play a crucial role in urinary bladder overactivity and incontinence during pregnancy.
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