Evidence map›Paper›PMID 29569183›Full record

ArticlePflugers Archiv : European journal of physiology2018

TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.

Kana Ohashi, Ayane Deyashiki, Takahito Miyake, Kazuki Nagayasu, Koji Shibasaki, Hisashi Shirakawa, Shuji Kaneko

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Physiology of Oligodendroglia.Advances in neurobiology · 2025
    Review
  3. Review
  4. Article
  5. Calcium and Neural Stem Cell Proliferation.International journal of molecular sciences · 2024
    Review
  6. Astrocytic TRPV4 Channels and Their Role in Brain Ischemia.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kana OhashiDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Ayane DeyashikiDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Takahito MiyakeDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Kazuki NagayasuDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Koji ShibasakiDepartment of Molecular and Cellular Neurology, Graduate School of Medicine, Gunma University, Maebashi, 371-8511, Japan.
Hisashi ShirakawaDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan. shirakaw@pharm.kyoto-u.ac.jp.ORCID 0000-0002-4129-0978
Shuji KanekoDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Kyoto University · JPGunma University · JP

Funding

Japan Society for the Promotion of Science KAKENHI 17K19486Japan Society for the Promotion of Science KAKENHI 24390016Japan Society for the Promotion of Science KAKENH JP15H03000Japan Society for the Promotion of Science London KAKENHI JP15H05934
6 · The paper itself

Abstract

Oligodendrocytes, which differentiate from oligodendrocyte precursor cells (OPCs), ensheath axons with myelin, play an essential role in rapid conduction of action potentials and metabolically support neurons. Elucidation of the mechanisms underlying the proliferation, migration, differentiation, and survival of OPCs is considered indispensable for determining the causes of central nervous system diseases. However, the relationship between these functions of OPCs and their intracellular Ca

Indexed as

AnimalsCalciumCell DifferentiationCell ProliferationCells, CulturedNeural Stem CellsOligodendrogliaRatsRats, WistarTRPV Cation ChannelsCalciumTrpv4 protein, ratTRPV Cation ChannelsCa2+ imagingCell proliferationOligodendrocyte precursor cellsProtein kinase CTRPV4 channel

Identifiers

PMID29569183
OpenAlexW2789978260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.