ArticleEndocrine2018
Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma'anshan Birth Cohort Study.
Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Incidence and trend of preterm birth in China, 1990-2016: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum.Frontiers in endocrinology · 2020Pooled it
- Trial
- Short- and Long-Term Consequences of Late-Preterm and Early-Term Birth.Children (Basel, Switzerland) · 2025Review
- Article
- Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study.Frontiers in endocrinology · 2023Article
- Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes.Frontiers in endocrinology · 2022Review
- Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China.European journal of pediatrics · 2021Article
- Variations in the Antithyroid Antibody Titre During Pregnancy and After Delivery.Risk management and healthcare policy · 2021Article
- Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Non-Malignant Nodular Goiter.International journal of general medicine · 2021Article
- Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study.BMC pregnancy and childbirth · 2020Article
- The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy.Disease markers · 2020Review
- Thyroid function reference ranges during pregnancy in a large Chinese population and comparison with current guidelines.Chinese medical journal · 2019Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
purposeWe aim to investigate associations of maternal serum anti-thyroperoxidase autoantibody (TPOAb) with duration of gestation. We aim to investigate whether maternal TPOAb positivity is associated with the risk of premature or early term birth.
methodsThis was a prospective birth cohort study performed in an iodine sufficient area of China. Serum samples were collected from 2931 women at both the first and second trimesters of pregnancy. Thyrotropin (TSH), free thyroxine (FT4), and TPOAb levels were measured. Data on gestational age at birth was obtained from delivery records.
resultsThe prevalence of early term birth was 23.8%, while the prevalence of premature birth was 4.2%. The prevalence of TPOAb positivity was 12.1% in the first trimester and was 7.2% in the second trimester. Gestational age at birth was inversely associated with lgTPOAb both in the first trimester (β, -0.283, 95% CI -0.408, -0.158; P < 0.001) and in the second trimester (β, -0.174, 95% CI -0.319, -0.030; P = 0.018), after adjustment for potential confounding factors. There was a positive association of TPOAb positivity with the risk of early term birth both in the first (OR = 1.691, 95% CI 1.302, 2.197) and second trimesters (OR = 1.644, 95% CI 1.193, 2.264), after adjustment for potential confounding factors. TPOAb positivity in the second trimester was associated with a 1.863-fold higher risk of premature birth (OR = 1.863, 95% CI 1.009, 3.441), after adjustment for potential confounding factors.
conclusionsOur results show that TPOAb is associated with shorter duration of gestation and with higher risk of premature and early term birth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.