Trial reportJournal of clinical monitoring and computing2018
Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension.
Trial report in Journal of clinical monitoring and computing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03872570 (Comparison of the Hemodynamic Effects of Phenylephrine and Norepinephrine in Patients Undergoing Deep Inferior Epigastric Perforator), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Hemodynamic Effects of Phenylephrine and Norepinephrine in Patients Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Surgery.
Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Development and evaluation of an automated phenylephrine delivery system by lower limit control for managing intraoperative hypotension.Journal of anesthesia · 2025Trial
- Effects of dobutamine and phenylephrine on cerebral perfusion in patients undergoing cerebral bypass surgery: a randomised crossover trial.British journal of anaesthesia · 2020Trial
- Comparison of propofol aloneWorld journal of methodology · 2026Article
- Alterations in arterial pressure waveform morphology following volume loading versus vasopressor administration in critically ill patients.Journal of clinical monitoring and computing · 2026Article
- Pharmacologic Strategies for Intraoperative Hypotension When Ephedrine Is Unavailable: An Evidence-Based Review.Journal of personalized medicine · 2026Review
- Association between continuous phenylephrine infusion and hemodynamic stability in patients undergoing gastrointestinal endoscopy under remimazolam sedation: a retrospective cohort study.BMC anesthesiology · 2026Article
- Investigating the potential of the isometric handgrip exercise as a test of cardiovascular reactivity to blood pressure fluctuations.BMC anesthesiology · 2026Observational
- Review
- The Anrep effect in septic shock: a mechanism of cardiac adaptation.British journal of anaesthesia · 2025Article
- Spectroscopic, quantum chemical, and topological calculations of the phenylephrine molecule using density functional theory.Scientific reports · 2025Article
- Article
- Dynamic Estimation of Cardiovascular State From Arterial Blood Pressure Recordings.IEEE transactions on bio-medical engineering · 2024Article
- Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients.Journal of clinical monitoring and computing · 2024Article
- In vivo optical assessment of cerebral and skeletal muscle microvascular response to phenylephrine.FASEB bioAdvances · 2024Article
- A retrospective study of the effects of a vasopressor bolus on systolic slope (dP/dt) and dynamic arterial elastance (EaBMC anesthesiology · 2024Observational
- Assessing changes in regional cerebral hemodynamics in adults with a high-density full-head coverage time-resolved near-infrared spectroscopy device.Journal of biomedical optics · 2024Article
- The Effect of Intraoperative Hypotension on Postoperative Renal Function.Current anesthesiology reports · 2023Article
- Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer.Breast cancer research : BCR · 2023Article
- Norepinephrine combined with phenylephrine versus norepinephrine in patients with septic shock: a retrospective cohort study.BMC infectious diseases · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induction of general anesthesia frequently induces arterial hypotension, which is often treated with a vasopressor, such as phenylephrine. As a pure α-agonist, phenylephrine is conventionally considered to solely induce arterial vasoconstriction and thus increase cardiac afterload but not cardiac preload. In specific circumstances, however, phenylephrine may also contribute to an increase in venous return and thus cardiac output (CO). The aim of this study is to describe the initial time course of the effects of phenylephrine on various hemodynamic variables and to evaluate the ability of advanced hemodynamic monitoring to quantify these changes through different hemodynamic variables. In 24 patients, after induction of anesthesia, during the period before surgical stimulus, phenylephrine 2 µg kg
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