Observational studyHeart and vessels2018
Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study.
Observational study in Heart and vessels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- BNP and NT-proBNP as prognostic biomarkers for the prediction of adverse outcomes in HFpEF patients: A systematic review and meta-analysis.Heart failure reviews · 2025Pooled it
- Characteristics and long-term prognosis of patients with reduced, mid-range, and preserved ejection fraction: A systemic review and meta-analysis.Clinical cardiology · 2022Pooled it
- Natriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction-a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Association of Time-to-Peak of Renal Blood Flow with Outcomes in Heart Failure: An Exploratory Comparative Analysis with Conventional Predictors.Balkan medical journal · 2026Observational
- Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation.Clinical interventions in aging · 2025Article
- Clinical Utility of Machine Learning-Derived Vocal Biomarkers in the Management of Heart Failure.Circulation reports · 2024Article
- Biomarkers in Heart Failure with Preserved Ejection Fraction: A Perpetually Evolving Frontier.Journal of clinical medicine · 2024Review
- Novel Strategies in Diagnosing Heart Failure with Preserved Ejection Fraction: A Comprehensive Literature Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Review
- Heart Failure with Preserved Ejection Fraction: The Pathophysiological Mechanisms behind the Clinical Phenotypes and the Therapeutic Approach.International journal of molecular sciences · 2024Review
- Assessment of the diagnostic value of NT-proBNP in heart failure with preserved ejection fraction.The British journal of cardiology · 2024Article
- Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left-sided heart diseases.ESC heart failure · 2023Article
- How to Use Natriuretic Peptides in Patients with Heart Failure with Non-Reduced Ejection Fraction?Anatolian journal of cardiology · 2023Article
- Heart failure with preserved ejection fraction in post myocardial infarction patients: a myocardial magnetic resonance (MR) tissue tracking study.Quantitative imaging in medicine and surgery · 2023Article
- Worsening effect of testosterone deficiency on males with heart failure with preserved ejection fraction.BMC endocrine disorders · 2022Article
- Clinical impact of admission urinary 8-hydroxydeoxyguanosine level for predicting cardiovascular mortality in patients with acute coronary syndrome.Heart and vessels · 2021Observational
- Left atrial diameter and atrial fibrillation, but not elevated NT-proBNP, predict the development of pulmonary hypertension in patients with HFpEF.Journal of geriatric cardiology : JGC · 2020Article
- Heart Failure with Preserved Ejection Fraction-a Concise Review.Current cardiology reports · 2020Review
- Prediction of cardiac events using fully automated GLS and BNP titers in patients with known or suspected heart failure.PloS one · 2020Article
- Use of speckle tracking to assess heart failure with preserved ejection fraction.Journal of cardiology · 2019Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
We aimed to compare the usefulness of plasma levels of B-type natriuretic peptide (BNP) for long-term risk stratification among patients with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HFpEF), borderline HFpEF, and HF with reduced LVEF (HFrEF) in the same HF cohort. In the CHART-2 Study (N = 10,219), we categorized 4301 consecutive Stage C/D HF patients (mean age 68.7 years, female 32.4%) into 3 groups: HFpEF (LVEF ≥ 50%, N = 2893), borderline HFpEF (LVEF 40-50%, N = 666), and HFrEF (LVEF ≤ 40%, N = 742). During the median 6.3-year follow-up, all-cause deaths occurred in 887 HFpEF, 330 borderline HFpEF, and 330 HFrEF patients. Although median BNP levels increased from HFpEF, borderline HFpEF to HFrEF (85.3, 126 and 208 pg/ml, respectively, P < 0.001), the relationship between log
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Registered trials
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