ArticleMolecular medicine reports2018
miR-590-3p mediates melatonin-induced cell apoptosis by targeting septin 7 in the human osteoblast cell line hFOB 1.19.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms.Journal of pineal research · 2025Review
- Chronobiology and Chronotherapy in Inflammatory Joint Diseases.Pharmaceutics · 2021Review
- Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases.Oncogene · 2021Article
- Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs.Advances in experimental medicine and biology · 2021Review
- Reconsidering the Role of Melatonin in Rheumatoid Arthritis.International journal of molecular sciences · 2020Review
- LncRNA RP1-85F18.6 affects osteoblast cells by regulating the cell cycle.Open life sciences · 2020Article
- STAT3 speeds up progression of osteoarthritis through NF-κB signaling pathway.Experimental and therapeutic medicine · 2020Article
- G-protein-coupled estrogen receptor suppresses the migration of osteosarcoma cells via post-translational regulation of Snail.Journal of cancer research and clinical oncology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate the association between septin 7 (SEPT7) and melatonin-induced apoptosis in the human fetal osteoblastic cell line hFOB 1.19. MicroRNA (miR)‑590‑3p was identified by identifying overlapping miRNAs that target SEPT7, across different databases (miRDB, DIANA and Targetscan). Apoptosis was assessed via flow cytometric analysis. Small interfering RNA of SEPT7 and a miR‑590‑3p inhibitor were used for gene silencing and the efficiency was assessed by reverse transcription‑quantitative polymerase chain reaction. Western blotting was used to measure the expression of proteins associated with pathways mediating endoplasmic reticulum stress and melatonin‑induced apoptosis. The present study identified that SEPT7 was a potential target of miR‑590‑3p and demonstrated that SEPT7 is associated with mediating the pro‑apoptotic effect of miR‑590‑3p in human osteoblast cell line hFOB 1.19. High concentrations of melatonin may result in the inhibition of miR‑590‑3p expression, leading to the upregulation of target genes that promote apoptosis.
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Registered trials
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