ArticleInternational journal of molecular medicine2018
Abnormal expression of fibrosis markers, estrogen receptor α and stromal derived factor‑1/chemokine (C‑X‑C motif) receptor‑4 axis in intrauterine adhesions.
Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Increased risk of hypertrophic scarring in estrogen receptor-positive breast cancer: a bidirectional mendelian randomization study.Archives of dermatological research · 2025Pooled it
- A novel intrauterine estrogen-releasing system for preventing the postoperative recurrence of intrauterine adhesion: a multicenter randomized controlled study.BMC medicine · 2024Trial
- Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice.BMC microbiology · 2023Trial
- A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions.Clinics (Sao Paulo, Brazil) · 2021Trial
- HFTMSCs alleviate uterine fibrosis and restore fertility in intrauterine adhesion models.Reproductive biology and endocrinology : RB&E · 2026Article
- Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells.Regenerative therapy · 2025Review
- LncRNA MALAT1 Knockdown Alleviates Fibrogenic Response in Human Endometrial Stromal Cells Via the miR-22-3p/TGFβR1/Smad2/3 Pathway.Cell biochemistry and biophysics · 2024Article
- Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function.Biological research · 2024Article
- Establishment and comparison of different procedures for modeling intrauterine adhesion in rats: A preliminary study.Heliyon · 2024Article
- Decoding the endometrial niche of Asherman's Syndrome at single-cell resolution.Nature communications · 2023Article
- Evaluation of different rat models intrauterine adhesion models and improvement of the technique for their establishment.Experimental animals · 2023Article
- Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers.Stem cells translational medicine · 2023Article
- Mycobiome Dysbiosis in Women with Intrauterine Adhesions.Microbiology spectrum · 2022Article
- Estradiol and intrauterine device treatment for moderate and severe intrauterine adhesions after transcervical resection.BMC women's health · 2022Article
- Cell-based therapy in thin endometrium and Asherman syndrome.Stem cell research & therapy · 2022Review
- EndMT: New findings on the origin of myofibroblasts in endometrial fibrosis of intrauterine adhesions.Reproductive biology and endocrinology : RB&E · 2022Article
- Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion.Frontiers in genetics · 2022Review
- Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury.Stem cell research & therapy · 2021Review
- Recent Advances in Understandings Towards Pathogenesis and Treatment for Intrauterine Adhesion and Disruptive Insights from Single-Cell Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrauterine adhesions (IUAs) are mainly derived from fibrous tissue formation following endometrial damage. The aim of the present study was to assess whether fibrosis markers, estrogen receptor (ER)α and the stromal derived factor (SDF)‑1/C‑X‑C chemokine receptor type 4 (CXCR‑4) axis are abnormally expressed in IUA endometrium. A total of 76 human endometrial biopsy samples (normal, n=20; mild‑to‑moderate IUAs, n=40; and severe IUAs, n=16) were employed, and Sprague‑Dawley rat IUA models at different time points were constructed. Subsequently, the expression of transforming growth factor (TGF)‑β1, matrix metalloproteinase (MMP)‑9, ERα and the SDF‑1/CXCR‑4 axis was evaluated in human and rat IUAs using histology, immunohistochemistry, reverse transcription quantitative polymerase chain reaction and western blotting. In patients and rats with IUA formation, the expression of TGF‑β1, MMP‑9 and ERα was significantly higher compared with the control group at the mRNA and protein levels (P<0.05); in addition, in patients, the TGF‑β1, MMP‑9 and ERα levels were significantly higher in severe IUAs compared with those in mild‑to‑moderate IUA endometrium (P<0.05). Although the chemokine SDF‑1 level in rats increased significantly during the early postoperative phase (reaching a peak at the second estrus phase) in rat endometrium (P<0.05), its special receptor CXCR‑4 expression did not differ significantly compared with the control group in rats or patients (P>0.05). Our findings indicated that aberrant activation of fibrosis and expression of ERα may be involved in the pathology of IUA formation. The role of the SDF‑1/CXCR‑4 axis in IUAs as inflammatory medium in the short‑term or special homing factors for bone marrow mesenchymal stem cells requires further verification in in vivo animal models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.