ReviewChemical Society reviews2018
Ratiometric optical nanoprobes enable accurate molecular detection and imaging.
Review in Chemical Society reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
152 citing papers in PubMed.
- Activatable NIR-II photoacoustic probes for cancer imaging and imaging-guided therapy.Bioactive materials · 2026Review
- Ratiometric Quantum Dot Nanosensor for Reliable Dual Detection of Silver Ions and L-Cysteine in Biological Matrices.Journal of fluorescence · 2026Article
- Ratiometric Fluorescence Sensing of Aflatoxin B1 Using a Cationic Perylene Probe and Rhodamine B.Journal of fluorescence · 2026Article
- Engineering LE-CT State Synergy in Aminoboranes for Single Molecule White Light Emission and Dual-Mode Chiroptical/Phosphorescence Output.Angewandte Chemie (International ed. in English) · 2026Article
- Nanoconfinement-Driven Solid-State Ratiometric Fluorescent Aptasensor for 17β-Estradiol Detection in Complex Matrices.Biosensors · 2026Article
- Functional DNAzyme-Guided Target Identification and Portable Detection of Colorectal Cancer.JACS Au · 2026Article
- Engineered dual-fluorescence functional nucleic acid-based CRISPR/Cas12a biosensor for label-free ratiometric detection of site-specific DNA methylation.Synthetic and systems biotechnology · 2026Article
- A three-dimensional A-D-A structured, [2.2]paracyclophane linked organoboron complex displays masked dual fluorescence and solvatofluorochromism.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Carbon Quantum Dot-Based Sensors: Photochemical Principles and Multimodal Applications.Materials (Basel, Switzerland) · 2026Review
- AND-Logic-Based Dual-Lock Hemicyanine Fluorescence Probe for Accurate Hypoxia Assessment in Tumors.Chemical & biomedical imaging · 2026Article
- In vivo ultrasound-induced luminescence imaging via trianthracene derivatives nanomaterials.Nature protocols · 2026Review
- Autofluorescence-free ratiometric temperature monitoring with multiple emissive persistent luminescent nanothermometers.Analytical and bioanalytical chemistry · 2026Article
- Advancements in nanobiosensors for early cancer detection, challenges, treatment, and future prospects: a comprehensive review.Discover nano · 2026Review
- Induced-Fit Recognition by a Calixarene-Pyrene Conjugate for Single- and Dual-Wavelength Fluorescence Sensing in Water.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis.Nature communications · 2026Article
- Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications.Journal of pharmaceutical analysis · 2026Review
- Construction of a ratiometric fluorescent detection platform based on dual emission bands of terbium(Ⅲ) ion for sensing of MnOMikrochimica acta · 2025Article
- A Facile Ratiometric Fluorescent Biosensor Using Blue-emitting Carbon Dots and Acriflavine for Quantitative Detection of DNA.Journal of fluorescence · 2025Article
- Single-walled carbon nanotubes sensors: Preparation and bio-application advances.Pharmaceutical science advances · 2025Review
- AI-Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Exploring and understanding biological and pathological changes are of great significance for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have experienced major progress in this field. Particularly, an emergence of various functional optical nanoprobes has provided enhanced sensitivity, specificity, targeting ability, as well as multiplexing and multimodal capabilities due to improvements in their intrinsic physicochemical and optical properties. However, one of the biggest challenges of conventional optical nanoprobes is their absolute intensity-dependent signal readout, which causes inaccurate sensing and imaging results due to the presence of various analyte-independent factors that can cause fluctuations in their absolute signal intensity. Ratiometric measurements provide built-in self-calibration for signal correction, enabling more sensitive and reliable detection. Optimizing nanoprobe designs with ratiometric strategies can surmount many of the limitations encountered by traditional optical nanoprobes. This review first elaborates upon existing optical nanoprobes that exploit ratiometric measurements for improved sensing and imaging, including fluorescence, surface enhanced Raman scattering (SERS), and photoacoustic nanoprobes. Next, a thorough discussion is provided on design strategies for these nanoprobes, and their potential biomedical applications for targeting specific biomolecule populations (e.g. cancer biomarkers and small molecules with physiological relevance), for imaging the tumor microenvironment (e.g. pH, reactive oxygen species, hypoxia, enzyme and metal ions), as well as for intraoperative image guidance of tumor-resection procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.