Evidence map›Paper›PMID 29568809›Full record

ArticleNanoImpact2016

Effects of engineered nanomaterial exposure on macrophage innate immune function.

Glen DeLoid, Beatriz Casella, Sandra Pirela, Rose Filoramo, Georgios Pyrgiotakis, Philip Demokritou, Lester Kobzik

Open access · greenAbstract read
In one paragraph

Article in NanoImpact, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Glen DeLoidCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Beatriz CasellaCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Sandra PirelaCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Rose FiloramoCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Georgios PyrgiotakisCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Lester KobzikCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States of America.
Brigham and Women's Hospital · USUniversidade de São Paulo · BR

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Increasing use of engineered nanomaterials (ENMs) means increased human exposures. Potential adverse effects include those on the immune system, ranging from direct toxicity to impairment of defenses against environmental pathogens and toxins. Effects on lung macrophages may be especially prominent, because they serve to clear foreign materials like ENMs and bacterial pathogens. We investigated the effects of 4 hour exposures over a range of concentrations, of a panel of industry-relevant ENMs, including SiO

Indexed as

engineered nanomaterialFrancisella tularensishost defenseinnate immunitymacrophagephagocytosis

Identifiers

PMID29568809
PMCPMC5860825
OpenAlexW2496123608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.