Trial reportBioMed research international2018
Temporal Change of Interleukin-6, C-Reactive Protein, and Skin Temperature after Total Knee Arthroplasty Using Triclosan-Coated Sutures.
Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02533492 (Compare the Results of Antimicrobial to Conventional Suture Materials in Patients Receiving Primary Total Knee Replacement), which is not on this map. Cited by 15 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Compare the Results of Antimicrobial to Conventional Suture Materials in Patients Receiving Primary Total Knee Replacement: A Prospective Double-blinded Randomized Controlled Trial
Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Triclosan-Containing Sutures for the Prevention of Surgical Site Infection: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- The Use of Biomarkers to Quantify Clinical Response to Total Knee Arthroplasty Interventions: A Systematic Review.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Pooled it
- Plus Sutures for preventing surgical site infection: a systematic review of clinical outcomes with economic and environmental models.BMC surgery · 2023Pooled it
- Natural history of changes in knee skin temperature following total knee arthroplasty: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- The role of triclosan-coated suture in preventing surgical infection: A meta-analysis.Joint diseases and related surgery · 2023Pooled it
- The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.BMJ open · 2019Pooled it
- Inflammatory phenotypes after total knee arthroplasty: a testable framework for biomarker-stratified enhanced recovery and precision rehabilitation.Frontiers in medicine · 2026Article
- Do Antibacterial Skin Sutures Reduce Surgical Site Infections After Elective Open Abdominal Surgery?-A Prospective, Randomized Controlled Single-Center Trial.Journal of clinical medicine · 2024Article
- Global mapping of institutional and hospital-based (Level II-IV) arthroplasty registries: a scoping review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis.Microorganisms · 2022Review
- Multilayer Watertight Closure to Address Adverse Events From Primary Total Knee and Hip Arthroplasty: A Systematic Review of Wound Closure Methods by Tissue Layer.Arthroplasty today · 2021Article
- Prevention of Periprosthetic Joint Infection (PJI): A Clinical Practice Protocol in High-Risk Patients.Tropical medicine and infectious disease · 2020Review
- Article
- Randomised controlled trial of triclosan coatedWorld journal of orthopedics · 2019Review
- Current Use of Infrared Thermography in Orthopaedic and Bone or Joint Trauma Patients-Can We Identify Postoperative Infection? A Narrative Systematic Review.Strategies in trauma and limb reconstructionReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of surgical site infections (SSIs) after total knee arthroplasty (TKA) can never be eliminated. Antimicrobial sutures containing triclosan have been used to decrease SSIs, but whether triclosan-coated sutures are effective with TKA is unclear. Between 2011 and 2012, 102 patients randomly assigned to a triclosan or a control group were prospectively assessed. The incidence of SSI within 3 months of surgery, length of hospital stay, pain scale, functional scores, wound condition, and serum inflammatory markers during hospitalization and within 3 months postoperatively were compared. At the final follow-up, there were 2 patients with superficial infections (3.9%) in the control group but none in the triclosan group. Lower serum IL-6 was detected in the triclosan group at 4 weeks and 3 months. The local skin temperature of the knees-recorded at 3 months using infrared thermography-was lower in the triclosan group than in the control group. More precise analytical measurements are needed to investigate local and systemic complications, especially in the early subclinical stage. This prospective, randomized, open-label clinical trial is in the public registry: ClinicalTrials.gov (NCT02533492).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.