ArticleBioMed research international2018
Anterior Capsule of the Lens: Comparison of Morphological Properties and Apoptosis Induction following FLACS and Standard Phacoemulsification Surgery.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Laser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Efficacy and safety analysis of LenSX and Catalys femtosecond laser systems in short axial length patients.Lasers in medical science · 2026Trial
- Trial
- Update on Femtosecond Laser-Assisted Cataract Surgery: A Review.Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- Femtosecond laser-assisted cataract surgery: Update and perspectives.Frontiers in medicine · 2023Review
- Intraoperative complications of cataract surgery using a low-energy femtosecond laser: Results from a real-world high-volume setting.PloS one · 2022Article
- Surgical outcomes with high and low pulse energy femtosecond laser systems for cataract surgery.Scientific reports · 2021Article
- Long-Term Evaluation of Capsulotomy Shape and Posterior Capsule Opacification after Low-Energy Bimanual Femtosecond Laser-Assisted Cataract Surgery.Journal of ophthalmology · 2020Article
- Evaluation of macular pigment optical density following femtosecond laser-assisted cataract surgery.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeComparative evaluation of morphological features of anterior capsules and apoptosis induction in epithelial cells after femtosecond laser-assisted cataract surgery (FLACS) and standard phacoemulsification surgery.
methodsGroup 1: 30 FLACS anterior capsulotomies and Group 2: 30 manual anterior continuous curvilinear capsulorhexes. All patients were operated on by the same experienced surgeon. Morphological features of the anterior capsules and apoptosis induction in epithelial cells were evaluated.
resultsAll patients revealed a significant mean best-corrected visual acuity (BCVA) improvement 3 months after surgery, and no major intraoperative nor postoperative complications occurred. The capsular epithelium appeared to be preserved in both groups. Scanning electron microscopy analysis revealed irregular saw-tooth shaped edges in capsules from Group 1 whereas capsules from Group 2 showed regular and smooth edges. A statistically significant higher expression of the downstream apoptotic effector cleaved caspase 3 was observed in Group 1.
conclusionsThe saw-tooth appearance was likely due to the progressive sequence of laser pulses on the capsule. The low energy/high frequency properties of the laser pulse, combined with an overlapped pulse pattern, resulted in highly continuous morphology of capsule edges. The higher apoptosis induction in FLACS group might be due to photodisruption-dependent plasma generation and formation of cavitation bubbles.
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