Evidence map›Paper›PMID 29568762›Full record

Observational studyBioMed research international2018

Compromised Dynamic Cerebral Autoregulation in Patients with Epilepsy.

Shan Lv, Zhen-Ni Guo, Hang Jin, Xin Sun, Meiyan Jia, Hongyin Ma, Yudan Lv, Quanli Qiu, Jia Liu, Yi Yang

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02775682 (Cerebral Autoregulation in Patients With Epilepsy), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02775682 completednot on this map

Cerebral Autoregulation in Patients With Epilepsy

TypeobservationalSponsorYi YangRan2016 to 2017Enrolled200ConditionsEpilepsy
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Spinal cord reversible cerebral vasoconstriction syndrome.Proceedings (Baylor University. Medical Center) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shan LvDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0003-4878-7490
Zhen-Ni GuoClinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Hang JinDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Xin SunDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Meiyan JiaDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-8375-5139
Hongyin MaDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Yudan LvDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Quanli QiuShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
Jia LiuShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.ORCID 0000-0002-5357-2163
Yi YangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-9729-8522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study is to analyze dynamic cerebral autoregulation (dCA) in patients with epilepsy.

methodsOne hundred patients with epilepsy and 100 age- and sex-matched healthy controls were recruited. Noninvasive continuous cerebral blood flow velocity of the bilateral middle artery and arterial blood pressure were recorded. Transfer function analyses were used to analyze the autoregulatory parameters (phase difference and gain).

resultsThe overall phase difference of patients with epilepsy was significantly lower than that of the healthy control group (

conclusionsOur study documented that dCA is impaired in patients with epilepsy, especially in those with interictal slow wave. The impairment of dCA occurs irrespective of the discharge location and type. Interictal slow wave is an independent factor to predict impaired dCA in patients with epilepsy. CLINICAL TRIAL IDENTIFIER: This trial is registered with NCT02775682.

Indexed as

AdultBlood Flow VelocityBlood PressureCerebellumCerebrovascular CirculationEpilepsyFemaleHomeostasisHumansMaleMiddle AgedUltrasonography, Doppler, Transcranial

Identifiers

PMID29568762
PMCPMC5820585

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.