Evidence map›Paper›PMID 29568746›Full record

ArticleBioMed research international2018

Metagenomics Biomarkers Selected for Prediction of Three Different Diseases in Chinese Population.

Honglong Wu, Lihua Cai, Dongfang Li, Xinying Wang, Shancen Zhao, Fuhao Zou, Ke Zhou

Abstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Honglong WuWuhan National Laboratory for Optoelectronics, Key Laboratory of Information Storage System, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
Lihua CaiWuhan National Laboratory for Optoelectronics, Key Laboratory of Information Storage System, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
Dongfang LiWuhan National Laboratory for Optoelectronics, Key Laboratory of Information Storage System, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
Xinying WangBinhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, Tianjin 300308, China.
Shancen ZhaoBGI-Shenzhen, Shenzhen 518083, China.
Fuhao ZouSchool of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
Ke ZhouWuhan National Laboratory for Optoelectronics, Key Laboratory of Information Storage System, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.ORCID 0000-0002-2161-8796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dysbiosis of human microbiome has been proven to be associated with the development of many human diseases. Metagenome sequencing emerges as a powerful tool to investigate the effects of microbiome on diseases. Identification of human gut microbiome markers associated with abnormal phenotypes may facilitate feature selection for multiclass classification. Compared with binary classifiers, multiclass classification models deploy more complex discriminative patterns. Here, we developed a pipeline to address the challenging characterization of multilabel samples. In this study, a total of 300 biomarkers were selected from the microbiome of 806 Chinese individuals (383 controls, 170 with type 2 diabetes, 130 with rheumatoid arthritis, and 123 with liver cirrhosis), and then logistic regression prediction algorithm was applied to those markers as the model intrinsic features. The estimated model produced an

Indexed as

AlgorithmsArthritis, RheumatoidAsian PeopleBiomarkersDiabetes Mellitus, Type 2DysbiosisFemaleHumansLiver CirrhosisMaleMetagenomeMetagenomicsMicrobiotaMiddle AgedROC CurveBiomarkers

Identifiers

PMID29568746
PMCPMC5820663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.