ReviewCurrent behavioral neuroscience reports2017
Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder.
Review in Current behavioral neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Literature Review of Neuroimaging of Psychopathic Traits.Frontiers in psychiatry · 2019Pooled it
- A Study of Candidate Genes Associated with Suicide Attempts in the Kazakh Population in Astana, Kazakhstan.International journal of molecular sciences · 2026Article
- Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.Journal of personalized medicine · 2022Article
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- The use of buprenorphine/naloxone to treat borderline personality disorder: a case report.Borderline personality disorder and emotion dysregulation · 2022Article
- Variable number tandem repeats - Their emerging role in sickness and health.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression.Translational psychiatry · 2021Review
- Risk and resilience for alcohol use disorder revealed in brain functional connectivity.NeuroImage. Clinical · 2021Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China.BMC psychiatry · 2020Article
- Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.Frontiers in behavioral neuroscience · 2020Article
- Association between aromatase in human brains and personality traits.Scientific reports · 2018Article
- Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior.The international journal of neuropsychopharmacology · 2018Article
- Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewVariation in the monoamine oxidase A (MAO-A) gene and MAO-A enzyme levels have been linked to antisocial behavior and aggression in clinical and non-clinical populations. Here, we provide an overview of the genetic, epigenetic, and neuroimaging research that has examined MAO-A structure and function in antisocial personality disorder (ASPD) and borderline personality disorder (BPD). RECENT
findingsThe low-activity MAO-A variable nucleotide tandem repeat genetic polymorphism has shown a robust association with large samples of violent and seriously violent offenders, many of whom had ASPD. A recent positron emission tomography (PET) study of ASPD similarly revealed low MAO-A density in brain regions thought to contribute to the psychopathology of the condition. By contrast, PET has also demonstrated that brain MAO-A levels are increased in BPD and that they relate to symptoms of low mood and suicidality. SUMMARY: Candidate gene studies have produced the most compelling evidence connecting MAO-A genetic variants to both ASPD and BPD. Still, conflicting results abound in the literature, making it highly unlikely that ASPD or BPD is related to a specific MAO-A genetic variant. Future research should strive to examine how MAO-A genotypes interact with broad-spectrum environmental influences to produce brain endophenotypes that may ultimately become tractable targets for novel treatment strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.