ArticleSouthern African journal of HIV medicine2016
Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV-infected individuals.
Article in Southern African journal of HIV medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Molecular neuroimaging of inflammation in HIV.Clinical and experimental immunology · 2022Review
- Associations between recent thymic emigrants and CD4+ T-cell recovery after short-term antiretroviral therapy initiation.AIDS (London, England) · 2020Article
- Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART.Viruses · 2019Review
- HIV as a Cause of Immune Activation and Immunosenescence.Mediators of inflammation · 2017Review
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Authors and funding
3 authors.
Funding
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Abstract
backgroundReduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation and thymic function in asymptomatic HIV-positive treatment-naive individuals has thus far not been investigated. AIMS AND
objectivesTo optimise a five-colour flow cytometric assay for measurement of thymic function by measuring recent thymic emigrants (RTEs) in treatment-naive HIV-infected patients and healthy controls and correlate results with levels of immune activation, CD4 counts and viral load.
methodsBlood obtained from 53 consenting HIV-positive individuals and 32 controls recruited from HIV prevention and testing clinic in Cape Town, South Africa. RTEs were measured (CD3
resultsHIV-infected individuals had reduced frequencies of RTEs when compared to controls (
conclusionsThere was impaired thymic function in HIV-infected individuals, which was associated with increased levels of immune activation. The thymic dysfunction was not associated with CD4 counts and viral load. Immune activation may result in inflammatory damage to the thymus and subsequent thymic dysfunction, and CD4 counts and viral load may not necessarily reflect thymic dysfunction in HIV.
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