Evidence map›Paper›PMID 29568605›Full record

ArticleSouthern African journal of HIV medicine2016

PIMA™ point-of-care testing for CD4 counts in predicting antiretroviral initiation in HIV-infected individuals in KwaZulu-Natal, Durban, South Africa.

Mandisa Skhosana, Shabashini Reddy, Tarylee Reddy, Siphelele Ntoyanto, Elizabeth Spooner, Gita Ramjee, Noluthando Ngomane, Anna Coutsoudis, Photini Kiepiela

Open access · goldAbstract read
In one paragraph

Article in Southern African journal of HIV medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mandisa SkhosanaDepartment of Paediatrics and Child Health, University of KwaZulu-Natal, South Africa.
Shabashini ReddyMedical Research Council of South Africa, HIV Prevention Research Unit, South Africa.
Tarylee ReddyMedical Research Council of South Africa, Biostatistics Unit, South Africa.
Siphelele NtoyantoMedical Research Council of South Africa, HIV Prevention Research Unit, South Africa.
Elizabeth SpoonerDepartment of Paediatrics and Child Health, University of KwaZulu-Natal, South Africa.
Gita RamjeeMedical Research Council of South Africa, HIV Prevention Research Unit, South Africa.ORCID 0000-0003-1524-6778
Noluthando NgomaneeThekwini Health Unit, eThekwini Municipality, South Africa.
Anna CoutsoudisDepartment of Paediatrics and Child Health, University of KwaZulu-Natal, South Africa.
Photini KiepielaMedical Research Council of South Africa, HIV Prevention Research Unit, South Africa.
South African Medical Research Council · ZAeThekwini Municipality · ZAUniversity of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLimited information is available on the usefulness of the PIMA™ analyser in predicting antiretroviral treatment eligibility and outcome in a primary healthcare clinic setting in disadvantaged communities in KwaZulu-Natal, South Africa. MATERIALS AND

methodsThe study was conducted under the eThekwini Health Unit, Durban, KwaZulu-Natal. Comparison of the enumeration of CD4+ T-cells in 268 patients using the PIMA™ analyser and the predicate National Health Laboratory Services (NHLS) was undertaken during January to July 2013. Bland-Altman analysis to calculate bias and limits of agreement, precision and levels of clinical misclassification at various CD4+ T-cell count thresholds was performed.

resultsThere was high precision of the PIMA™ control bead cartridges with low and normal CD4+ T-cell counts using three different PIMA™ analysers (%CV < 5). Under World Health Organization (WHO) guidelines (≤ 500 cells/mm

conclusionThere was adequate agreement between PIMA™ analyser and predicate NHLS CD4+ T-cell count enumeration (≤ 500 cells/mm

Identifiers

PMID29568605
PMCPMC5843260
OpenAlexW2467048515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.