ArticleJournal of pharmaceutical health care and sciences2018
Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysis.
Article in Journal of pharmaceutical health care and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Unraveling the impact of renal impairment and renal replacement therapy modalities on fluconazole pharmacokinetics.European journal of clinical pharmacology · 2025Review
- Therapeutic Drug Monitoring Is a Feasible Tool to Personalize Drug Administration in Neonates Using New Techniques: An Overview on the Pharmacokinetics and Pharmacodynamics in Neonatal Age.International journal of molecular sciences · 2020Review
- Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities.Paediatric drugs · 2020Review
- Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants.CPT: pharmacometrics & systems pharmacology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluconazole is frequently prescribed for the treatment of systemic fungal infection in neonates and infants. At present, prediction of fluconazole doses according to developmental changes in fluconazole clearance is not being done in these patients. We aimed to formulate a developmental model of fluconazole clearance taking into account the ontogeny of renal function, since the drug is largely eliminated renally.
methodsWe systematically retrieved the data of fluconazole pharmacokinetics and renal function in children and adults from databases (MEDLINE and Japan Medical Abstracts Society). Datasets were retrieved from individual children or groups from 9 studies comprising 55 neonates or infants at postmenstrual age (PMA) 27-58 weeks. Datasets were retrieved from 5 studies comprising 60 children and from 13 studies comprising 152 adults. Datasets of glomerular filtration rate (GFR) for individual pediatric subjects were retrieved from 4 studies comprising 187 neonates or infants.
resultsFluconazole clearance normalized to body surface area (BSA) (CL
conclusionsThe present study indicates that fluconazole doses for neonates and infants may be predicted from developmental change of systemic clearance, the ontogeny of which parallels the maturation of nephron function.
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