ArticleAntimicrobial resistance and infection control2018
Prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients at Peking Union Medical College Hospital.
Article in Antimicrobial resistance and infection control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- Microbiological Spectrum and Antimicrobial Resistance Patterns of Cerebrospinal Fluid Isolates from Neurosurgical Intensive Care and Ward Patients: A 10-Year Single-Center Study.Journal of clinical medicine · 2026Article
- Gut microbiota and SCFA signatures in predicting postoperative infection sites in neurocritical care patients.Frontiers in microbiology · 2026Article
- Recent advances in diagnostic technologies for postoperative central nervous system infections: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Study on cerebrospinal fluid meropenem, vancomycin and tigecycline monitoring in patients with central nervous system infection following neurosurgery under different drug regimens.Frontiers in pharmacology · 2025Article
- A novel dynamic nomogram based on clinical features and laboratory indicators for diagnosis of post-neurosurgery intracranial infection.Translational neuroscience · 2025Article
- Prevalence and antibiotic resistance of pathogens isolated from neurosurgical patients with postoperative central nervous system infections in a tertiary hospital in North China.Frontiers in public health · 2025Article
- Clinical characteristics and prognosis ofHeliyon · 2024Article
- Clinical characteristics and antimicrobial therapy of healthcare-associated carbapenem-non-susceptible gram-negative bacterial meningitis: a 16-year retrospective cohort study.BMC infectious diseases · 2024Observational
- Development and Validation of a Nomograph Model for Post-Operative Central Nervous System Infection after Craniocerebral Surgery.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci.Caspian journal of internal medicine · 2022Article
- Hypervirulent carbapenem-resistantFrontiers in public health · 2022Article
- Epidemiology of patients with central nervous system infections, mainly neurosurgical patients: a retrospective study from 2012 to 2019 in a teaching hospital in China.BMC infectious diseases · 2021Article
- Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii.Scientific reports · 2021Article
- Epidemiology and Drug Resistance of Pathogens Isolated from Cerebrospinal Fluids at a Children's Medical Center in Eastern China During 2006-2020.Infection and drug resistance · 2021Article
- Total Laboratory Automation and Three Shifts Reduce Turnaround Time of Cerebrospinal Fluid Culture Results in the Chinese Clinical Microbiology Laboratory.Frontiers in cellular and infection microbiology · 2021Article
- Epidemiological Characteristics and Drug Resistance Analysis of Cerebrospinal Fluid Microbial Infections in Wenzhou Area.Infection and drug resistance · 2021Article
- Application of combined cerebrospinal fluid physicochemical parameters to detect intracranial infection in neurosurgery patients.BMC neurology · 2020Article
- High prevalence of KPC-2-producing hypervirulentInfection and drug resistance · 2019Article
- Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative central nervous system infections (PCNSIs) represent a serious complication, and the timely use of antibiotics guided by the identification of the causative pathogens and their antibiotic sensitivities is essential for treatment. However, there are little data regarding the prevalence of PCNSI pathogens in China. The aim of this study is to investigate the features of pathogens in patients with PCNSIs, which could help clinicians to choose the appropriate empirical antibiotic therapy. Methods: We retrospectively examined the positive CSF cultures in patients who underwent craniotomy between January 2010 and December 2015. We collected data, including demographic characteristics, type of neurosurgery, laboratory data, causative organisms and antimicrobial susceptibility testing results. Results: A total of 62 patients with 90 isolates out of 818 patients with 2433 CSF culture samples were available for data analysis. The estimated incidence and culture-positive rate of PCNSIs were approximately 0.9 and 7.5%, respectively. The predominant organism was coagulase-negative staphylococci, of which most were methicillin-resistant coagulase-negative staphylococci (MRCoNS). All were susceptible to vancomycin, linezolid, rifampicin and amoxicillin-clavulanate. Conclusion: PCNSIs could lead to high mortality. Although the MRCoNS were the predominant organism, the management of
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