Evidence map›Paper›PMID 29568478›Full record

ArticleJournal of tissue engineering

Toward a patient-specific tissue engineered vascular graft.

Cameron Best, Robert Strouse, Kan Hor, Victoria Pepper, Amy Tipton, John Kelly, Toshiharu Shinoka, Christopher Breuer

Open access · goldAbstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Biological Scaffolds for Congenital Heart Disease.Bioengineering (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Review
  9. Tunable Blood Shunt for Neonates With Complex Congenital Heart Defects.Frontiers in bioengineering and biotechnology · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Building Blood Vessels with Vascular Progenitor Cells.Trends in molecular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cameron BestCenter for Regenerative Medicine, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Robert StrouseResearch Innovation and Solutions, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Kan HorDepartment of Cardiology, The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Victoria PepperCenter for Regenerative Medicine, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Amy TiptonAdvanced Cardiac Imaging Laboratory, The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
John KellyCenter for Regenerative Medicine, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Toshiharu ShinokaCenter for Regenerative Medicine, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Christopher BreuerCenter for Regenerative Medicine, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Nationwide Children's Hospital · USThe Ohio State University · US

Funding

Improving Tissue Engineered Vascular Graft Performance via Computational ModelingR01HL139796 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2018 to 2025
$6.4M
Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular GraftsR01HL098228 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE · 2010 to 2018
$3.6M
Training in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5M
NHLBI NIH HHS R01 HL098228NHLBI NIH HHS R01 HL139796NHLBI NIH HHS T32 HL098039
6 · The paper itself

Abstract

Integrating three-dimensional printing with the creation of tissue-engineered vascular grafts could provide a readily available, patient-specific, autologous tissue source that could significantly improve outcomes in newborns with congenital heart disease. Here, we present the recent case of a candidate for our tissue-engineered vascular graft clinical trial deemed ineligible due to complex anatomical requirements and consider the application of three-dimensional printing technologies for a patient-specific graft. We 3D-printed a closed-disposable seeding device and validated that it performed equivalently to the traditional open seeding technique using ovine bone marrow-derived mononuclear cells. Next, our candidate's preoperative imaging was reviewed to propose a patient-specific graft. A seeding apparatus was then designed to accommodate the custom graft and 3D-printed on a commodity fused deposition modeler. This exploratory feasibility study represents an important proof of concept advancing progress toward a rationally designed patient-specific tissue-engineered vascular graft for clinical application.

Indexed as

3D-printingcell seedingFontan operationpatient-specific modelingTissue-engineered vascular graft

Identifiers

PMID29568478
PMCPMC5858675
OpenAlexW2792114057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.