ArticleComputational and mathematical methods in medicine2018
Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions.
Article in Computational and mathematical methods in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanobiological Dysregulation of Fibroblasts and Extracellular Matrix Failure in Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Finite element-based prioritization of pelvic floor muscles for rehabilitation to maintain urinary and fecal control in elderly women.Frontiers in physiology · 2025Article
- A new epoxy for plastination: feasibility and applicability analysis of the conservation of biological tissues.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Finite element modeling in obstetrics and gynecology: advances, applications, and challenges.Frontiers in medicine · 2025Review
- Quantifying the effects of five rehabilitation training methods on the ability of elderly men to control bowel movements: a finite element analysis study.Frontiers in bioengineering and biotechnology · 2024Article
- Anatomical investigation of the pelvic urogenital fascia in 10 formalin-fixed female cadavers: novel insights into the laparoscopic total mesometrial resection.BMC surgery · 2023Article
- Small Extracellular Vesicles Secreted by Peri-urethral Tissues Regulate Fibroblast Function and Contribute to the Pathogenesis of Female Stress Urinary Incontinence.Current medical science · 2023Article
- Distinctive structure, composition and biomechanics of collagen fibrils in vaginal wall connective tissues associated with pelvic organ prolapse.Acta biomaterialia · 2022Article
- Layer-Specific Damage Modeling of Porcine Large Intestine under Biaxial Tension.Bioengineering (Basel, Switzerland) · 2022Article
- Impact of treatment modality on pelvic floor dysfunction among uterine cancer survivors.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2022Article
- The evolution of pelvic canal shape and rotational birth in humans.BMC biology · 2021Article
- A computational analysis of the effect of supporting organs on predicted vesical pressure in stress urinary incontinence.Medical & biological engineering & computing · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.