ArticleMicrofluidics and nanofluidics2018
Oligosaccharide model of the vascular endothelial glycocalyx in physiological flow.
Article in Microfluidics and nanofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Model of Neutrophil Chemotaxis Participated by the Vascular Endothelial Glycocalyx.International journal of general medicine · 2025Review
- A comprehensive physics-based model for the brachial Artery's full flow mediated dilation (FMD) response observed during the FMD test.Computers in biology and medicine · 2024Article
- A framework for the simulation of individual glycan coordinates to analyze spatial relationships within the glycocalyx.Frontiers in cell and developmental biology · 2024Article
- Role of blood flow in endothelial functionality: a review.Frontiers in cell and developmental biology · 2023Review
- On the examination of the viscous response of the brachial artery during flow-mediated dilation.Journal of the mechanical behavior of biomedical materials · 2022Article
- Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism.Stem cell reports · 2022Article
- On the modeling of mechanotransduction in flow-mediated dilation.Journal of the mechanical behavior of biomedical materials · 2021Article
- Understanding the Role of Endothelial Glycocalyx in Mechanotransduction via Computational Simulation: A Mini Review.Frontiers in cell and developmental biology · 2021Review
- Membrane Deformation of Endothelial Surface Layer Interspersed with Syndecan-4: A Molecular Dynamics Study.Annals of biomedical engineering · 2020Article
- Concurrent coupling of atomistic simulation and mesoscopic hydrodynamics for flows over soft multi-functional surfaces.Soft matter · 2019Article
- Reducing Salt Intake and Exercising Regularly: Implications From Molecular Dynamics Simulations of Endothelial Glycocalyx.Frontiers in physiology · 2018Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Experiments have consistently revealed the pivotal role of the endothelial glycocalyx layer in vasoregulation and the layer's contribution to mechanotransduction pathways. However, the exact mechanism by which the glycocalyx mediates fluid shear stress remains elusive. This study employs atomic-scale molecular simulations with the aim of investigating the conformational and orientation properties of highly flexible oligosaccharide components of the glycocalyx and their suitability as transduction molecules under hydrodynamic loading. Fluid flow was shown to have nearly no effect on the conformation populations explored by the oligosaccharide, in comparison with static (diffusion) conditions. However, the glycan exhibited a significant orientation change, when compared to simple diffusion, aligning itself with the flow direction. It is the tethered end of the glycan, an asparagine amino acid, which experienced conformational changes as a result of this flow-induced bias. Our results suggest that shear flow through the layer can have an impact on the conformational properties of saccharide-decorated transmembrane proteins, thus acting as a mechanosensor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.