ArticleProceedings of SPIE--the International Society for Optical Engineering
Comparison of quantitative myocardial perfusion imaging CT to fluorescent microsphere-based flow from high-resolution cryo-images.
Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- The Fading Art of Microsphere-Derived Measurement of Absolute Myocardial Blood Flow.Annals of nuclear cardiology · 2025Review
- Optimal slice thickness for improved accuracy of quantitative analysis of fluorescent cell and microsphere distribution in cryo-images.Scientific reports · 2023Article
- Spleen Tissue Segmentation Algorithm for Cryo-Imaging Data.Journal of digital imaging · 2023Article
- Static CT myocardial perfusion imaging: image quality, artifacts including distribution and diagnostic performance compared toEuropean journal of hybrid imaging · 2022Article
- SLICR super-voxel algorithm for fast, robust quantification of myocardial blood flow by dynamic computed tomography myocardial perfusion imaging.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- Calibration-free beam hardening correction for myocardial perfusion imaging using CT.Medical physics · 2019Article
- The role of acquisition and quantification methods in myocardial blood flow estimability for myocardial perfusion imaging CT.Physics in medicine and biology · 2018Article
- SLIC robust (SLICR) processing for fast, robust CT myocardial blood flow quantification.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Effect of Beam Hardening on Transmural Myocardial Perfusion Quantification in Myocardial CT Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Myocardial perfusion imaging using CT (MPI-CT) has the potential to provide quantitative measures of myocardial blood flow (MBF) which can aid the diagnosis of coronary artery disease. We evaluated the quantitative accuracy of MPI-CT in a porcine model of balloon-induced LAD coronary artery ischemia guided by fractional flow reserve (FFR). We quantified MBF at baseline (FFR=1.0) and under moderate ischemia (FFR=0.7) using MPI-CT and compared to fluorescent microsphere-based MBF from high-resolution cryo-images. Dynamic, contrast-enhanced CT images were obtained using a spectral detector CT (Philips Healthcare). Projection-based mono-energetic images were reconstructed and processed to obtain MBF. Three MBF quantification approaches were evaluated: singular value decomposition (SVD) with fixed Tikhonov regularization (ThSVD), SVD with regularization determined by the L-Curve criterion (LSVD), and Johnson-Wilson parameter estimation (JW). The three approaches over-estimated MBF compared to cryo-images. JW produced the most accurate MBF, with average error 33.3±19.2mL/min/100g, whereas LSVD and ThSVD had greater over-estimation, 59.5±28.3mL/min/100g and 78.3±25.6 mL/min/100g, respectively. Relative blood flow as assessed by a flow ratio of LAD-to-remote myocardium was strongly correlated between JW and cryo-imaging, with R
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