ArticleScientific reports2018
Inhibitory effect of surface pre-reacted glass-ionomer (S-PRG) eluate against adhesion and colonization by Streptococcus mutans.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05466461 (Clinical Assessment of Injectable Flowable Composite With Giomer Based Technology Versus Smart Bioactive Restoration in Carious Class V Cavities), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Assessment of Injectable Flowable Composite With Giomer Based Technology Versus Smart Bioactive Restoration in Carious Class V Cavities (A Randomized Clinical Trial)
Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Evaluation of Micro-Shear Bond Strength of Self-Adhesive Flowable Giomer To Bovine Tooth.The journal of adhesive dentistry · 2026Article
- Biological Effects on S-PRG: An Integrative Review.Journal of functional biomaterials · 2026Review
- Antibacterial activity of a bioactive composite resins containing surface pre-reacted glass in a complex multispecies subgingival biofilm.Odontology · 2026Article
- Isolation ofJournal of oral microbiology · 2026Article
- Blueberry leaf polyphenols suppress biofilm formation and restore oral microbial homeostasis for caries control.Journal of oral microbiology · 2026Article
- Pyruvate metabolism is involved in adaptability and cariogenicity ofJournal of oral microbiology · 2026Review
- Efficacy of sealants with surface pre-reacted glass (S-PRG) in retention, fissure penetration and occlusal caries Inhibition : Short title: efficacy of S-PRG sealants.Clinical oral investigations · 2025Article
- Resin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm.Scientific reports · 2025Article
- Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate onInternational journal of molecular sciences · 2024Article
- Surface Pre-Reacted Glass-Ionomer Eluate Suppresses Osteoclastogenesis through Downregulation of the MAPK Signaling Pathway.Biomedicines · 2024Article
- Suppression of Streptococcus mutans Biofilm Formation and Gene Expression by PRG Barrier Coat: A Molecular and Microscopic Study for Preventing Dental Caries.Oral health & preventive dentistry · 2024Article
- Inhibitory Effects of Shikonin Dispersion, an Extract ofInternational journal of molecular sciences · 2024Article
- Analysis of color stability and degree of conversion of different types of resin composites.Brazilian oral research · 2024Article
- Inhibitory Effect of Adsorption ofInternational journal of molecular sciences · 2023Article
- Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm.Pharmaceutics · 2023Article
- Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care.Journal of functional biomaterials · 2023Review
- Effect of Particle Sizes and Contents of Surface Pre-Reacted Glass Ionomer Filler on Mechanical Properties of Auto-Polymerizing Resin.Dentistry journal · 2023Article
- Article
- Impact of direct restorative dental materials on surface root caries treatment. Evidence based and current materials development: A systematic review.The Japanese dental science review · 2022Review
- Evaluation of the collagen-binding properties and virulence of killed Streptococcus mutans in a silkworm model.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface Pre-reacted Glass-ionomer (S-PRG) filler is a bioactive filler produced by PRG technology, which has been applied to various dental materials. A S-PRG filler can release multiple ions from a glass-ionomer phase formed in the filler. In the present study, detailed inhibitory effects induced by S-PRG eluate (prepared with S-PRG filler) against Streptococcus mutans, a major pathogen of dental caries, were investigated. S-PRG eluate effectively inhibited S. mutans growth especially in the bacterium before the logarithmic growth phase. Microarray analysis was performed to identify changes in S. mutans gene expression in the presence of the S-PRG eluate. The S-PRG eluate prominently downregulated operons related to S. mutans sugar metabolism, such as the pdh operon encoding the pyruvate dehydrogenase complex and the glg operon encoding a putative glycogen synthase. The S-PRG eluate inhibited several in vitro properties of S. mutans relative to the development of dental caries especially prior to active growth. These results suggest that the S-PRG eluate may effectively inhibit the bacterial growth of S. mutans following downregulation of operons involved in sugar metabolism resulting in attenuation of the cariogenicity of S. mutans, especially before the active growth phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.