Evidence map›Paper›PMID 29567993›Full record

ArticleNature reviews. Drug discovery2018

Unexplored therapeutic opportunities in the human genome.

Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Anna Gaulton, Shawn M Gomez, Rajarshi Guha, Anne Hersey, Jayme Holmes and 31 more

Abstract readPublished Erratum
PubMed Publisher
In one paragraph

Article in Nature reviews. Drug discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. A Forward Genetic Screen inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Drug Repurposing Using Molecular Network Analysis Identifies Jak as Targetable Driver in Necrobiosis Lipoidica.JID innovations : skin science from molecules to population health · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Future of Precision Oncology.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. The era of high-quality chemical probes.RSC medicinal chemistry · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Tudor I Oprea
Cristian G Bologa
Søren Brunak
Allen Campbell
Gregory N Gan
Anna Gaulton
Shawn M Gomez
Rajarshi Guha
Anne Hersey
Jayme Holmes
Ajit Jadhav
Lars Juhl Jensen
Gary L Johnson
Anneli Karlson
Andrew R Leach
Avi Ma'ayan
Anna Malovannaya
Subramani Mani
Steven L Mathias
Michael T McManus
Terrence F Meehan
Christian von Mering
Daniel Muthas
Dac-Trung Nguyen
John P Overington
George Papadatos
Jun Qin
Christian Reich
Bryan L Roth
Stephan C Schürer
Anton Simeonov
Larry A Sklar
Noel Southall
Susumu Tomita
Ilinca Tudose
Oleg Ursu
Dušica Vidovic
Anna Waller
David Westergaard
Jeremy J Yang
Gergely Zahoránszky-Köhalmi

Funding

Mouse Phenotyping Informatics Infrastructure - MP12UM1HG006370 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Pilar Cacheiro Martinez, Helen Elizabeth Parkinson · 2016 to 2026
$20.4M
Machine Learning Model Validation for AD/ADRDU24CA224370 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2018 to 2023
$6.4M
Illuminating the Druggable Genome Knowledge Management Center (IDG KMC)U54CA189205 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI OPREA, TUDOR I · 2014 to 2017
$5.7M
Resource Dissemination and Outreach Center for Illuminating the Druggable GenomeU24TR002278 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SCHURER, STEPHAN C, SKLAR, LARRY A. · 2018 to 2023
$3.7M
NCATS NIH HHS U24 TR002278NCI NIH HHS U24 CA224370NCI NIH HHS U54 CA189205
6 · The paper itself

Abstract

This corrects the article DOI: 10.1038/nrd.2018.14.

Identifiers

PMID29567993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.