ArticleScientific reports2018
Crotamine induces browning of adipose tissue and increases energy expenditure in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial.Scientific reports · 2021Trial
- Snake venom defensins: Defining the structural and functional characteristics of the toxin family.Journal of structural biology: X · 2025Article
- Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activityToxicon: X · 2024Article
- Proteomic analysis reveals rattlesnake venom modulation of proteins associated with cardiac tissue damage in mouse hearts.Journal of proteomics · 2022Article
- Synthetic polypeptide crotamine: characterization as a myotoxin and as a target of combinatorial peptides.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression.Science advances · 2020Article
- Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia.Frontiers in cell and developmental biology · 2020Review
- Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles.PLoS neglected tropical diseases · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crotamine, originally isolated from rattlesnake venom, has been extensively studied due to its pleiotropic biological properties, and special attention has been paid to its antitumor activity. However, long-term treatment with crotamine was accompanied by a reduction in animal body weight gain and by increases in glucose tolerance. As cancer is commonly associated with cachexia, to preclude the possible cancer cachexia-like effect of crotamine, herein this polypeptide was administered in healthy wild-type C57/BL6 mice by the oral route daily, for 21 days. Reduced body weight gain, in addition to decreased white adipose tissue (WAT) and increased brown adipose tissue (BAT) mass were observed in healthy animals in the absence of tumor. In addition, we observed improved glucose tolerance and increased insulin sensitivity, accompanied by a reduction of plasma lipid levels and decreased levels of biomarkers of liver damage and kidney disfunctions. Importantly, long-term treatment with crotamine increased the basal metabolic rate in vivo, which was consistent with the increased expression of thermogenic markers in BAT and WAT. Interestingly, cultured brown adipocyte cells induced to differentiation in the presence of crotamine also showed increases in some of these markers and in lipid droplets number and size, indicating increased brown adipocyte maturation.
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