ArticleScientific reports2018
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Honokiol-mediated reversal of cisplatin-induced transcriptomic changes in outer hair cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Sensory decline in aging and neurodegeneration: A mitochondrial perspective.Pharmacological research · 2026Review
- Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mitochondrial protein-enriched artificial nanovesicles: mitochondrial recovery and antioxidation for diabetic wound treatment.Journal of nanobiotechnology · 2026Article
- Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies.Redox report : communications in free radical research · 2025Review
- The Role and Research Progress of Mitochondria in Sensorineural Hearing Loss.Molecular neurobiology · 2025Review
- Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes.Frontiers in cell and developmental biology · 2025Review
- Advances in the Study of Etiology and Molecular Mechanisms of Sensorineural Hearing Loss.Cell biochemistry and biophysics · 2024Review
- Loss of Cisd2 Exacerbates the Progression of Age-Related Hearing Loss.Aging and disease · 2024Article
- Review
- Review
- In vivo investigation of mitochondria in lateral line afferent neurons and hair cells.Hearing research · 2023Review
- The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging.Hearing research · 2023Review
- IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders.Oncology letters · 2022Review
- Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea.Frontiers in aging neuroscience · 2022Article
- Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss.Frontiers in cell and developmental biology · 2022Article
- Review
- The KEAP1-NRF2 System in Healthy Aging and Longevity.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss.NPJ aging and mechanisms of disease · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Karessa WhiteDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Mi-Jung KimDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Chul HanDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Hyo-Jin ParkDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Dalian DingCenter for Hearing and Deafness, State University of New York at Buffalo, New York, 14214, United States.
Kevin BoydDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Logan WalkerDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Paul LinserWhitney Laboratory, University of Florida, St Augustine, Florida, 32080, United States.
Zaimary MenesesDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Cole SladeDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Jonathan HirstDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States.
Katherine SantostefanoDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, United States.
Naohiro TeradaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, United States.
Takuya MiyakawaDepartment of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, 113, Japan.
Masaru TanokuraDepartment of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, 113, Japan.ORCID 0000-0001-5072-2480
Richard SalviCenter for Hearing and Deafness, State University of New York at Buffalo, New York, 14214, United States.
Shinichi SomeyaDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida, 32610, United States. someya@ufl.edu.ORCID 0000-0001-9895-6227
University of Florida · USThe University of Tokyo · JPUniversity at Buffalo, State University of New York · USWhitney Museum of American Art · US
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8MCochlear Detoxification SystemR01DC014437 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2015 to 2019
$2.2MMitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing LossR01DC012552 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2013 to 2017
$1.9MThe Role of Glutathione Reductase in Age-related Hearing LossR03DC011840 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2011 to 2013
$432kNIA NIH HHS P30 AG028740NIDCD NIH HHS R01 DC012552NIDCD NIH HHS R01 DC014437NIDCD NIH HHS R03 DC011840
Abstract
Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP
Indexed as
AgingAnimalsApoptosisCell SurvivalCochleaDisease Models, AnimalGlutathione ReductaseHair Cells, AuditoryHearing LossHumansIsocitrate DehydrogenaseMaleMiceMitochondriaNADPNeuronsGlutathione ReductaseIsocitrate Dehydrogenaseisocitrate dehydrogenase 2, mouseNADPThioredoxin Reductase 2Txnrd2 protein, mouse
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.