ArticleNature communications2018
Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of locust phase polyphenism: from proximate mechanisms to ecology and management.PeerJ · 2026Pooled it
- Dopamine and its receptoreLife · 2026Article
- Article
- The Integrative Imperatives of Locust Phase Polyphenism Research: A Bibliometric Analysis.Integrative organismal biology (Oxford, England) · 2026Review
- Article
- Identification of miRNAs Involved in Olfactory Regulation in Antennae of Beet Webworm,Life (Basel, Switzerland) · 2024Article
- Comparative transcriptomics suggests a highly species-specific nature of the phenotypic plasticity associated with the outbreaks of the two main pest locusts.BMC genomics · 2024Article
- A midgut transcriptional regulatory loop favors an insect host to withstand a bacterial pathogen.Innovation (Cambridge (Mass.)) · 2024Article
- SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia.Nature communications · 2024Article
- Regulation of insect behavior by non-coding RNAs.Science China. Life sciences · 2024Review
- Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA.Nature communications · 2024Article
- MicroRNA ame-let-7 targets Amdop2 to increase sucrose sensitivity in honey bees (Apis mellifera).Frontiers in zoology · 2023Article
- 4-Vinylanisole promotes conspecific interaction and acquisition of gregarious behavior in the migratory locust.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cytosolic and mitochondrial ribosomal proteins mediate the locust phase transition via divergence of translational profiles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Glutamate-GABA imbalance mediated by miR-8-5p and its STTM regulates phase-related behavior of locusts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Sulfation modification of dopamine in brain regulates aggregative behavior of animals.National science review · 2022Article
- Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts.EMBO reports · 2022Article
- Chemical Ecology and Olfaction in Short-Horned Grasshoppers (Orthoptera: Acrididae).Journal of chemical ecology · 2022Review
- Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp,Insects · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine receptor 1 (Dop1) mediates locust attraction behaviors, however, the mechanism by which Dop1 modulates this process remains unknown to date. Here, we identify differentially expressed small RNAs associated with locust olfactory attraction after activating and inhibiting Dop1. Small RNA transcriptome analysis and qPCR validation reveal that Dop1 activation and inhibition downregulates and upregulates microRNA-9a (miR-9a) expression, respectively. miR-9a knockdown in solitarious locusts increases their attraction to gregarious volatiles, whereas miR-9a overexpression in gregarious locusts reduces olfactory attraction. Moreover, miR-9a directly targets adenylyl cyclase 2 (ac2), causing its downregulation at the mRNA and protein levels. ac2 responds to Dop1 and mediates locust olfactory attraction. Mechanistically, Dop1 inhibits miR-9a expression through inducing the dissociation of La protein from pre-miR-9a and resulting in miR-9a maturation inhibition. Our results reveal a Dop1-miR-9a-AC2 circuit that modulates locust olfactory attraction underlying aggregation. This study suggests that miRNAs act as key messengers in the GPCR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.