Evidence map›Paper›PMID 29567865›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

Indomethacin Enhances Brown Fat Activity.

Lei Hao, Jamie Kearns, Sheyenne Scott, Dayong Wu, Sean D Kodani, Christophe Morisseau, Bruce D Hammock, Xiaocun Sun, Ling Zhao, Shu Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Lei HaoDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Jamie KearnsDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Sheyenne ScottDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Dayong WuDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Sean D KodaniDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Christophe MorisseauDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Bruce D HammockDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Xiaocun SunDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.).
Ling ZhaoDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.) shu.wang@ttu.edu ling.zhao@utk.edu.
Shu WangDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas (L.H., S.S., S.W.); Department of Nutrition (J.K., L.Z.), and Research Computing Support (X.S.), University of Tennessee, Knoxville, Tennessee; Nutrition Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts (D.W.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (S.D.K., C.M., B.D.H.) shu.wang@ttu.edu ling.zhao@utk.edu.
Tufts University · USUC Davis Comprehensive Cancer CenterUniversity of California, Davis · USJean Mayer Human Nutrition Research Center on Aging · USWestern Human Nutrition Research Center · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
Eicosanoid-based Therapy for DiabetesR01DK103616 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI IMIG, JOHN D · 2015 to 2019
$2.4M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Anti-obesity effects of adipose-targeting resveratrol nanocarriersR15AT008733 · NCCIH · TEXAS TECH UNIVERSITY · PI WANG, SHU · 2015 to 2015
$395k
Green Tea Nanocarriers: A Promising Approach for the Prevention and Treatment ofR15AT007013 · NCCIH · TEXAS TECH UNIVERSITY · PI WANG, SHU · 2011 to 2011
$314k
NCCIH NIH HHS R15 AT007013NCCIH NIH HHS R15 AT008733NIDDK NIH HHS R01 DK103616NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown. To address this issue, we treated mouse brown preadipocytes with different doses of indomethacin, and delivered indomethacin to interscapular BAT (iBAT) of obese mice using implanted osmotic pumps. Indomethacin dose dependently increased brown preadipocyte differentiation and upregulated both mRNA and protein expression of uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor (PPAR)

Indexed as

AdipocytesAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsCell DifferentiationCell LineIndomethacinMiceObesityIndomethacin

Identifiers

PMID29567865
PMCPMC5931432
OpenAlexW2790398420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.