Evidence map›Paper›PMID 29567849›Full record

ArticleBMJ open2018

Diagnostic accuracy of self-administered urine glucose test strips as a diabetes screening tool in a low-resource setting in Cambodia.

Helen L Storey, Maurits H van Pelt, Socheath Bun, Frances Daily, Tina Neogi, Matthew Thompson, Helen McGuire, Bernhard H Weigl

Abstract readComparative Study
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helen L StoreyPATH, Seattle, Washington, USA.
Maurits H van PeltMoPoTsyo Patient Information Centre, Phnom Penh, Cambodia.
Socheath BunMoPoTsyo Patient Information Centre, Phnom Penh, Cambodia.
Frances DailyMoPoTsyo Patient Information Centre, Phnom Penh, Cambodia.
Tina NeogiPATH, Seattle, Washington, USA.
Matthew ThompsonDepartment of Family Medicine, University of Washington, Seattle, Washington, USA.
Helen McGuirePATH, Washington, District of Columbia, USA.
Bernhard H WeiglPATH, Seattle, Washington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveScreening for diabetes in low-resource countries is a growing challenge, necessitating tests that are resource and context appropriate. The aim of this study was to determine the diagnostic accuracy of a self-administered urine glucose test strip compared with alternative diabetes screening tools in a low-resource setting of Cambodia.

designProspective cross-sectional study.

settingMembers of the Borey Santepheap Community in Cambodia (Phnom Penh Municipality, District Dangkao, Commune Chom Chao).

participantsAll households on randomly selected streets were invited to participate, and adults at least 18 years of age living in the study area were eligible for inclusion. OUTCOMES: The accuracy of self-administered urine glucose test strip positivity, Hemoglobin A1c (HbA1c)>6.5% and capillary fasting blood glucose (cFBG) measurement ≥126 mg/dL were assessed against a composite reference standard of cFBGmeasurement ≥200 mg/dL or venous blood glucose 2 hours after oral glucose tolerance test (OGTT) ≥200 mg/dL.

resultsOf the 1289 participants, 234 (18%) had diabetes based on either cFBG measurement (74, 32%) or the OGTT (160, 68%). The urine glucose test strip was 14% sensitive and 99% specific and failed to identify 201 individuals with diabetes while falsely identifying 7 without diabetes. Those missed by the urine glucose test strip had lower venous fasting blood glucose, lower venous blood glucose 2 hours after OGTT and lower HbA1c compared with those correctly diagnosed.

conclusionsLow cost, easy to use diabetes tools are essential for low-resource communities with minimal infrastructure. While the urine glucose test strip may identify persons with diabetes that might otherwise go undiagnosed in these settings, its poor sensitivity cannot be ignored. The massive burden of diabetes in low-resource settings demands improvements in test technologies.

Indexed as

AdultAgedCambodiaCross-Sectional StudiesDiabetes MellitusFalse Negative ReactionsFalse Positive ReactionsFemaleGlucose Tolerance TestGlycated HemoglobinGlycosuriaHumansLogistic ModelsMaleMass ScreeningMiddle AgedGlycated HemoglobinReagent Stripsdiabetesdiagnosticslow-resource settingsscreeningurine glucose test strip

Identifiers

PMID29567849
PMCPMC5875619

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.