Evidence map›Paper›PMID 29567829›Full record

ArticleCancer discovery2018

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Smruti Pushalkar, Mautin Hundeyin, Donnele Daley, Constantinos P Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana E Torres and 23 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 932 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
932citing papers in PubMed, 4 pooled it
39.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

932 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,318 citations in OpenAlex.

  1. Pooled it
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  5. Axitinib plus Avelumab in Recurrent/Metastatic Adenoid Cystic Carcinoma: Biomarker Analysis and Updated Results of the Phase II Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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872 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 4 institutions in 1 country.

Smruti Pushalkar *Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Mautin Hundeyin *S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Donnele Daley *S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Constantinos P ZambirinisS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Emma KurzS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Ankita MishraS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Navyatha MohanS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Berk AykutS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Mykhaylo UsykDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Luisana E TorresS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Gregor WerbaS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Kevin ZhangDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Yuqi GuoDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Qianhao LiDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Neha AkkadS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Sarah LallS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Benjamin WadowskiS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Johana GutierrezS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Juan Andres Kochen RossiS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Jeremy W HerzogNational Gnotobiotic Rodent Research Center, University of North Carolina, Chapel Hill, North Carolina.
Brian DiskinS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Alejandro Torres-HernandezS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Josh LeinwandS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Wei WangS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Pardeep S TaunkS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Shivraj SavadkarS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Malvin JanalDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Anjana SaxenaDepartment of Epidemiology and Health Promotion, NYU College of Dentistry, New York, New York.
Xin LiDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Deirdre CohenDepartment of Biology, Brooklyn College and the Graduate Center (CUNY), Brooklyn, New York, New York.
R Balfour SartorNational Gnotobiotic Rodent Research Center, University of North Carolina, Chapel Hill, North Carolina.
Deepak SaxenaDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York. george.miller@nyumc.org ds100@nyu.edu.
George MillerS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York. george.miller@nyumc.org ds100@nyu.edu.
New York University · USUniversity of North Carolina at Chapel Hill · USThe Graduate Center, CUNY · USYork University · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
Toll-like Receptor Regulation of Pancreatic TumorigenesisR01CA168611 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COHEN, DEIRDRE, MILLER, GEORGE · 2013 to 2019
$2.1M
Regulation of Pancreatic Oncogenesis by the Gut MicrobiomeR01CA206105 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXENA, DEEPAK, SIMEONE, DIANE M · 2017 to 2021
$1.9M
Modulation of oral microenvironment by E-cigarette aerosol mixturesR01DE025992 · NIDCR · NEW YORK UNIVERSITY · PI LI, XIN, SAXENA, DEEPAK · 2016 to 2019
$1.6M
(PQA1) Novel epigenetic mechanism mediate metformin inhibition of prostate cancerR01CA180277 · NCI · NEW YORK UNIVERSITY · PI LI, XIN · 2013 to 2016
$1.1M
The Role of Dendritic Cells in Pancreatic TumorigenesisR21CA155649 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MILLER, GEORGE · 2011 to 2012
$404k
Role of nucleolin in regulating mRNA stability during DNA damage response (DDR)R21CA175794 · NCI · BROOKLYN COLLEGE · PI KLEIMAN, FRIDA E, SAXENA, ANJANA DEEPAK · 2013 to 2014
$365k
NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA168611NCI NIH HHS R01 CA180277NCI NIH HHS R01 CA206105NCI NIH HHS R21 CA155649NCI NIH HHS R21 CA175794NIDCR NIH HHS R01 DE025992NIDDK NIH HHS P30 DK034987NIGMS NIH HHS T32 GM007308NIH HHS P40 OD010995
6 · The paper itself

Abstract

We found that the cancerous pancreas harbors a markedly more abundant microbiome compared with normal pancreas in both mice and humans, and select bacteria are differentially increased in the tumorous pancreas compared with gut. Ablation of the microbiome protects against preinvasive and invasive pancreatic ductal adenocarcinoma (PDA), whereas transfer of bacteria from PDA-bearing hosts, but not controls, reverses tumor protection. Bacterial ablation was associated with immunogenic reprogramming of the PDA tumor microenvironment, including a reduction in myeloid-derived suppressor cells and an increase in M1 macrophage differentiation, promoting TH1 differentiation of CD4

Indexed as

CarcinogenesisMicrobiotaAnimalsBacteriaCell DifferentiationFemaleHumansMaleMiceMonocytesPancreatic NeoplasmsSignal TransductionToll-Like ReceptorsToll-Like Receptors

Identifiers

PMID29567829
PMCPMC6225783
OpenAlexW2790589159

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.