ArticleEMBO molecular medicine2018
Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis.
Open access · goldAbstract read
In one paragraph
Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond.Frontiers in immunology · 2022Pooled it
- IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease.Human genetics · 2021Trial
- The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice.Life (Basel, Switzerland) · 2026Article
- Enterococcus faecalis GP1764 induces an early differential gene expression in the intestine on key pathways related to cellular immune response and gut barrier function in chickens.Poultry science · 2026Article
- Evolving Therapeutic Paradigms in Pediatric Hypophosphatasia: From Survival-Driven Care to Integrated Precision Management.International journal of molecular sciences · 2026Review
- Alleviating the Adverse Effects of Lipopolysaccharide on Production Performance, Immune Function, and Intestinal Damage in Broilers via Dietary Alkaline Phosphatase.Animals : an open access journal from MDPI · 2026Article
- Tissue nonspecific and intestinal alkaline phosphatase crosstalk: a missing link in hypophosphatasia pathophysiology?Journal of translational medicine · 2026Article
- From Brewery Waste to Sustainable Aquafeed: HarnessingAquaculture nutrition · 2026Article
- Tissue-nonspecific alkaline phosphatase deficiency is associated with altered immune cell profiles in hypophosphatasia.Frontiers in immunology · 2026Article
- Toward Precision Medicine: Molecular Biomarkers of Response to Tofacitinib in Inflammatory Bowel Disease.Genes · 2025Review
- Neuraminidase-3 activity in toddlers negatively impacts the linear growth status in Bangladeshi children.Scientific reports · 2025Article
- Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis.International journal of molecular sciences · 2025Review
- Diagnosis and Treatment of Hypophosphatasia.Calcified tissue international · 2025Review
- Novel Role of theInternational journal of molecular sciences · 2024Article
- Inborn errors of immunity: an expanding universe of disease and genetic architecture.Nature reviews. Genetics · 2024Review
- Alkaline Phosphatase Relieves Colitis in Obese Mice Subjected to Forced Exercise via Its Anti-Inflammatory and Intestinal Microbiota-Shaping Properties.International journal of molecular sciences · 2024Article
- Intestinal permeability in patients undergoing stem cell transplantation correlates with systemic acute phase responses and dysbiosis.Blood advances · 2023Article
- Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease.International journal of molecular sciences · 2023Review
- Systemic effects of hypophosphatasia characterization of two novel variants in theFrontiers in endocrinology · 2023Article
- Intestinal Alkaline Phosphatase Activity and Efficiency Are Altered in Severe COVID-19 Patients.Gastro hep advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 3 countries.
Marianna ParlatoINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Fabienne Charbit-HenrionINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Jie PanSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Claudio RomanoGENIUS group from ESPGHAN.
Rémi Duclaux-LorasINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Marie-Helene Le DuDepartment of Biochemistry, Biophysics and Structural Biology, Institute for Integrative Biology of the Cell (I2BC), CEA, UMR 9198 CNRS, Université Paris-Sud, Gif-sur-Yvette, France.
Neil WarnerSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Paola FrancalanciDigestive Endoscopy and Surgery Unit and Pathology Unit Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
Julie BruneauUniversité Paris Descartes-Sorbonne Paris Cité, Paris, France.
Marc BrasBioinformatics Platform, Université Paris-Descartes-Paris Sorbonne Centre and Institut Imagine, Paris, France.
Mohammed ZarhrateGenomic Platform, INSERM, UMR1163, Imagine Institute, Paris Descartes-Sorbonne Paris Cite University, Paris, France.
Bernadette BègueINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Nicolas GueganINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Sabine RakotobeINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Nathalie KapelDepartment of Functional Coprology, Pitié Salpêtrière Hospital Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France.
Paola De AngelisDigestive Endoscopy and Surgery Unit and Pathology Unit Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
Anne M GriffithsSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Karoline FiedlerSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-5627-1916
Eileen CrowleySickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Frank RuemmeleINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France.
Aleixo M MuiseSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada aleixo.muise@sickkids.ca nadine.cerf-bensussan@inserm.fr.
Nadine Cerf-BensussanINSERM, UMR1163, Laboratory of Intestinal Immunity and Institut Imagine, Paris, France aleixo.muise@sickkids.ca nadine.cerf-bensussan@inserm.fr.ORCID 0000-0003-0665-1245
Délégation Paris 5 · FRSickKids Foundation · CAInserm · FRBambino Gesù Children's Hospital · ITInstitut des Maladies Génétiques Imagine · FRSorbonne Université · FRUniversité Paris-Sud · FRUniversity of Messina · ITUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report the first identification of biallelic-inherited mutations in
Indexed as
Alkaline PhosphataseGPI-Linked ProteinsHEK293 CellsHomeostasisHumansInflammatory Bowel DiseasesIntestinesMutationSignal TransductionAlkaline PhosphataseALPI protein, humanGPI-Linked Proteinsinflammatory bowel diseasesintestinal phosphatase alkalinemonogenic disease
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.