Evidence map›Paper›PMID 29567771›Full record

ArticleHaematologica2018

Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2.

Heike Horn, Christian Kohler, Raphael Witzig, Markus Kreuz, Ellen Leich, Wolfram Klapper, Michael Hummel, Markus Loeffler, Lorenz Trümper, Rainer Spang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

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  4. BMC medical imaging · 2026
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  15. An overview and a roadmap for artificial intelligence in hematology and oncology.Journal of cancer research and clinical oncology · 2023
    Review
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  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Heike HornDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Germany.
Christian KohlerStatistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg, Germany.
Raphael WitzigDepartment of Clinical Pathology, Robert Bosch Krankenhaus, Stuttgart, Germany.
Markus KreuzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany.
Ellen LeichInstitute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
Wolfram KlapperDepartment of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University Kiel, Germany.
Michael HummelInstitute of Pathology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany.
Lorenz TrümperDepartment of Hematology and Oncology, Georg-August University of Göttingen, Germany.
Rainer SpangStatistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg, Germany.
Andreas RosenwaldInstitute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
German OttDepartment of Clinical Pathology, Robert Bosch Krankenhaus, Stuttgart, Germany german.ott@rbk.de.
Molecular Mechanisms in Malignant Lymphomas (MMML) Network Project
Leipzig University · DERobert Bosch Hospital · DEUniversity of Regensburg · DECharité - Universitätsmedizin Berlin · DEComprehensive Cancer Center Mainfranken · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Göttingen · DEUniversity of Tübingen · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A linear progression model of follicular lymphomas (FL) FL1, FL2 and FL3A has been favored, since FL3A often co-exist with an FL1/2 component. FL3B, in contrast, is thought to be more closely related to diffuse large B-cell lymphoma (DLBCL), and both are often simultaneously present in one tumor (DLBCL/FL3B). To obtain more detailed insights into follicular lymphoma progression, a comprehensive analysis of a well-defined set of FL1/2 (n=22), FL3A (n=16), FL3B (n=6), DLBCL/FL3B (n=9), and germinal center B-cell-type diffuse large B-cell lymphoma (n=45) was undertaken using gene expression profiling, immunohistochemical stainings and genetic analyses by fluorescence

Indexed as

Genetic Association StudiesTranscriptomeAdultAgedBiomarkers, TumorComputational BiologyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryIn Situ Hybridization, FluorescenceLymphoma, FollicularMaleMiddle AgedNeoplasm GradingBiomarkers, Tumor

Identifiers

PMID29567771
PMCPMC6029545
OpenAlexW2789925257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.