ArticleJournal of the American Heart Association2018
Moderate-to-Vigorous Physical Activity and All-Cause Mortality: Do Bouts Matter?
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 100 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Synthesis and Validity of Accelerometer Devices and Methods Used in Epidemiological Studies of Physical Activity Bout Duration and Health Outcomes: A Systematic Review.Sports medicine - open · 2026Pooled it
- Physical inactivity in chronic airways disease: an important candidate in the treatable traits paradigm.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2019Guideline
- Association between Bout Duration of Physical Activity and Health: Systematic Review.Medicine and science in sports and exercise · 2019Pooled it
- Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.Medicine and science in sports and exercise · 2019Pooled it
- Experiences of mobile health in promoting physical activity: A qualitative systematic review and meta-ethnography.PloS one · 2018Pooled it
- Trial
- Adherence to a lower versus higher intensity physical activity intervention in the Breast Cancer & Physical Activity Level (BC-PAL) Trial.Journal of cancer survivorship : research and practice · 2022Trial
- Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial.Diabetes care · 2022Trial
- Validity, Reliability and Sensitivity to Change of Three Consumer-Grade Activity Trackers in Controlled and Free-Living Conditions among Older Adults.Sensors (Basel, Switzerland) · 2021Trial
- Waking-hour movement patterns and all-cause mortality: A multi-dimensional accelerometer analysis in the UK Biobank.Journal of exercise science and fitness · 2026Article
- The Relation of Within-Day Physical Activity Patterns With All-Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative.Arthritis care & research · 2026Observational
- Impact of physical activity patterns on major adverse cardiovascular events in adults with hypertension.British journal of sports medicine · 2026Article
- Physical activity partners for women with cardiovascular disease risk: Proof-of-concept trial with daily assessment.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Data from the UK Biobank demonstrates that increased brief, sporadic moderate-to-vigorous physical activity reduces mortality.Communications medicine · 2026Article
- Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Short-duration electrical pulse stimulation induces myokines and mitochondrial adaptations in C2C12 myotubes.Journal of muscle research and cell motility · 2026Article
- The Effect of an Immersive Virtual Reality Physical Activity Intervention on Anthropometric Variables, Physical Fitness, and Blood Pressure in College Students: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Vigorous intermittent lifestyle physical activity (VILPA) and mortality risk among US adults: a wearables-based national cohort study.The international journal of behavioral nutrition and physical activity · 2026Article
- Every move counts: but some more than others.The international journal of behavioral nutrition and physical activity · 2026Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundThe 2008 Physical Activity Guidelines for Americans recommends that adults accumulate moderate-to-vigorous physical activity (MVPA) in bouts of ≥10 minutes for substantial health benefits. To what extent the same amount of MVPA accumulated in bouts versus sporadically reduces mortality risk remains unclear. METHODS AND
resultsWe analyzed data from the National Health and Nutrition Examination Survey 2003-2006 and death records available through 2011 (follow-up period of ≈6.6 years; 700 deaths) to examine the associations between objectively measured physical activity accumulated with and without a bout criteria and all-cause mortality in a representative sample of US adults 40 years and older (n=4840). Physical activity data were processed to generate minutes per day of total and bouted MVPA. Bouted MVPA was defined as MVPA accumulated in bouts of a minimum duration of either 5 or 10 minutes allowing for 1- to 2-minute interruptions. Hazard ratios for all-cause mortality associated with total and bouted MVPA were similar and ranged from 0.24 for the third quartile of total to 0.44 for the second quartile of 10-minute bouts. The examination of jointly classified quartiles of total MVPA and tertiles of proportion of bouted activity revealed that greater amounts of bouted MVPA did not result in additional risk reductions for mortality.
conclusionsThese results provide evidence that mortality risk reductions associated with MVPA are independent of how activity is accumulated and can impact the development of physical activity guidelines and inform clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.