Evidence map›Paper›PMID 29567679›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.

Gertraud Erhart, Claudia Lamina, Terho Lehtimäki, Pedro Marques-Vidal, Mika Kähönen, Peter Vollenweider, Olli T Raitakari, Gérard Waeber, Barbara Thorand, Konstantin Strauch and 5 more

Open access · hybridAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 5 countries.

Gertraud ErhartFrom the Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria (G.E., C.L., F.K., S.C.).
Claudia LaminaFrom the Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria (G.E., C.L., F.K., S.C.).
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories (T.L.).
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Switzerland (P.M.-V., P.V., G.W.).
Mika KähönenFinnish Cardiovascular Research Center (T.L., M.K.).
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Switzerland (P.M.-V., P.V., G.W.).
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.).
Gérard WaeberDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Switzerland (P.M.-V., P.V., G.W.).
Barbara ThorandInstitute of Epidemiology II (B.T., C.G., A.P.).
Konstantin StrauchInstitute of Genetic Epidemiology (K.S., C.G.).
Christian GiegerInstitute of Epidemiology II (B.T., C.G., A.P.).
Thomas MeitingerInstitute of Human Genetics, Technische Universität München, Germany (T.M.).
Annette PetersInstitute of Epidemiology II (B.T., C.G., A.P.).
Florian KronenbergFrom the Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria (G.E., C.L., F.K., S.C.).
Stefan CoassinFrom the Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria (G.E., C.L., F.K., S.C.) stefan.coassin@i-med.ac.at.
Innsbruck Medical University · ATUniversity of Lausanne · CHGerman Center for Diabetes Research · DECardiovascular Research Center · BRHelmholtz Zentrum München · DELudwig-Maximilians-Universität München · DETampere University · FITechnical University of Munich · DEUniversität Innsbruck · ATUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLp(a) (lipoprotein(a)) concentrations are widely genetically determined by the APPROACH AND

resultsWe investigated Lp(a) concentrations,

conclusionsThe population differences in Lp(a) concentrations between Finnish and Central European populations originate not only from a different

Indexed as

Polymorphism, Single NucleotideAdultAgedApolipoproteins EFemaleFinlandGene FrequencyGenetics, PopulationHaplotypesHumansLipoprotein(a)MaleMiddle AgedPhenotypeProprotein Convertase 9Protein IsoformsApoE protein, humanApolipoproteins ELipoprotein(a)PCSK9 protein, humanProprotein Convertase 9Protein Isoformsatherosclerosisgenetics, populationlipoprotein(a)risk factors

Identifiers

PMID29567679
PMCPMC5943067
OpenAlexW2800621709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.